LongevityMap Gene
Gene details
- HGNC symbol
- PCNA
- Aliases
- ATLD2
- Common name
- proliferating cell nuclear antigen
- Description
- The protein encoded by this gene is found in the nucleus and is a cofactor of DNA polymerase delta. The encoded protein acts as a homotrimer and helps increase the processivity of leading strand synthesis during DNA replication. In response to DNA damage, this protein is ubiquitinated and is involved in the RAD6-dependent DNA repair pathway. Two transcript variants encoding the same protein have been found for this gene. Pseudogenes of this gene have been described on chromosome 4 and on the X chromosome. [provided by RefSeq, Jul 2008]
- Cytogenetic Location
- 20p12.3
- UCSC Genome Browser
- View 20p12.3 on the UCSC genome browser
- OMIM
- 176740
- Ensembl
- ENSG00000132646
- UniProt/Swiss-Prot
- PCNA_HUMAN
- Entrez Gene
- 5111
- UniGene
- 147433
- 1000 Genomes
- 1000 Genomes
Homologs in model organisms
- Caenorhabditis elegans
- pcn-1
- Danio rerio
- pcna
- Drosophila melanogaster
- PCNA
- Drosophila melanogaster
- CG10262
- Mus musculus
- Pcna
- Mus musculus
- Pcna-ps2
- Rattus norvegicus
- Pcna
- Saccharomyces cerevisiae
- POL30
- Schizosaccharomyces pombe
- pcn1
In other databases
Studies (1)
Significant/Non-significant: 0/1
- Longevity Association
- Non-significant
- Population
- Danish
- Study Design
- 592 SNPs from 77 genes involved in nine sub-processes were analyzed in 1089 long-lived and 736 middle-aged Danes. Then, a replicated study was carried out in a German cohort.
- Conclusions
- The results did not remain significant after correction. The findings drawn from the Danish cohort were not replicated in German samples.
- Indentifier
- rs8125170
- Reference