LongevityMap Gene
Gene details
- HGNC symbol
- MSH2
- Aliases
- FCC1; COCA1; HNPCC; LCFS2; HNPCC1
- Common name
- mutS homolog 2
- Description
- This locus is frequently mutated in hereditary nonpolyposis colon cancer (HNPCC). When cloned, it was discovered to be a human homolog of the E. coli mismatch repair gene mutS, consistent with the characteristic alterations in microsatellite sequences (RER+ phenotype) found in HNPCC. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012]
- Cytogenetic Location
- 2p21-p16.3
- UCSC Genome Browser
- View 2p21-p16.3 on the UCSC genome browser
- OMIM
- 609309
- Ensembl
- ENSG00000095002
- UniProt/Swiss-Prot
- MSH2_HUMAN
- Entrez Gene
- 4436
- UniGene
- 597656
- 1000 Genomes
- 1000 Genomes
Homologs in model organisms
- Caenorhabditis elegans
- msh-2
- Danio rerio
- msh2
- Drosophila melanogaster
- spel1
- Mus musculus
- Msh2
- Rattus norvegicus
- Msh2
- Saccharomyces cerevisiae
- MSH2
- Schizosaccharomyces pombe
- msh2
In other databases
- GenAge model organism genes
- CellAge gene expression
- This gene is present as MSH2
Studies (1)
Significant/Non-significant: 0/1
- Longevity Association
- Non-significant
- Population
- Danish
- Study Design
- 592 SNPs from 77 genes involved in nine sub-processes were analyzed in 1089 long-lived and 736 middle-aged Danes. Then, a replicated study was carried out in a German cohort.
- Conclusions
- The results did not remain significant after correction. The findings drawn from the Danish cohort were not replicated in German samples.
- Indentifier
- rs12999145
- Reference