LongevityMap Gene
Gene details
- HGNC symbol
- LONP1
- Aliases
- LON; LONP; PIM1; hLON; LonHS; CODASS; PRSS15
- Common name
- lon peptidase 1, mitochondrial
- Description
- This gene encodes a mitochondrial matrix protein that belongs to the Lon family of ATP-dependent proteases. This protein mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides in the mitochondrial matrix. It may also have a chaperone function in the assembly of inner membrane protein complexes, and participate in the regulation of mitochondrial gene expression and maintenance of the integrity of the mitochondrial genome. Decreased expression of this gene has been noted in a patient with hereditary spastic paraplegia (PMID:18378094). Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Feb 2013]
- Cytogenetic Location
- 19p13.3
- UCSC Genome Browser
- View 19p13.3 on the UCSC genome browser
- OMIM
- 605490
- Ensembl
- ENSG00000196365
- UniProt/Swiss-Prot
- LONM_HUMAN
- Entrez Gene
- 9361
- UniGene
- 350265
- 1000 Genomes
- 1000 Genomes
Homologs in model organisms
- Caenorhabditis elegans
- C34B2.6
- Danio rerio
- lonp1
- Drosophila melanogaster
- Lon
- Mus musculus
- Lonp1
- Rattus norvegicus
- Lonp1
- Saccharomyces cerevisiae
- PIM1
- Schizosaccharomyces pombe
- pim1
In other databases
- GenAge model organism genes
Studies (1)
Significant/Non-significant: 0/1
- Longevity Association
- Non-significant
- Population
- Danish
- Study Design
- 592 SNPs from 77 genes involved in nine sub-processes were analyzed in 1089 long-lived and 736 middle-aged Danes. Then, a replicated study was carried out in a German cohort.
- Conclusions
- The results did not remain significant after correction. The findings drawn from the Danish cohort were not replicated in German samples.
- Indentifier
- rs3892355
- Reference