LongevityMap variant group

Entry Details

Longevity Association: Non-significant
Population: Danish
Study Design: Two cohorts of middle aged (N = 708; 356 males and 352 females) and oldest old individuals (N = 908; 265 males and 643 females) were genotyped for UCP3 polymorphisms, hand grip performance and survival at old age
Conclusions: The study showed that after 10 years from the start of the project, a significant effect on survival chances was observed for rs11235972 and rs3781907, but not for rs1685354 or rs647126.

HGNC symbol: UCP3
Aliases: SLC25A9
Common name: uncoupling protein 3
Description: Mitochondrial uncoupling proteins (UCP) are members of the larger family of mitochondrial anion carrier proteins (MACP). UCPs separate oxidative phosphorylation from ATP synthesis with energy dissipated as heat, also referred to as the mitochondrial proton leak. UCPs facilitate the transfer of anions from the inner to the outer mitochondrial membrane and the return transfer of protons from the outer to the inner mitochondrial membrane. They also reduce the mitochondrial membrane potential in mammalian cells. The different UCPs have tissue-specific expression; this gene is primarily expressed in skeletal muscle. This gene's protein product is postulated to protect mitochondria against lipid-induced oxidative stress. Expression levels of this gene increase when fatty acid supplies to mitochondria exceed their oxidation capacity and the protein enables the export of fatty acids from mitochondria. UCPs contain the three solcar protein domains typically found in MACPs. Two splice variants have been found for this gene.[provided by RefSeq, Nov 2008]
Other longevity studies of this gene: 9
OMIM: 602044
Ensembl: ENSG00000175564
UniProt/Swiss-Prot: A0A0S2Z4G5_HUMAN
Entrez Gene: 7352
UniGene: 101337
HapMap: View on HapMap

GenAge human genes

Dato et al. (2012)