LongevityMap variant group
Entry Details
- Longevity Association
- Significant
- Population
- Chinese
- Study Design
- A 10-year follow-up study of the Chinese longitudinal healthy longevity survey was performed consisting of 963 long-lived and 1028 geography-matched young individuals. Sixteen SNPs from ADRB1, ADRB2, ADCY5, ADCY6, and MAPK1 were selected and genotyped.
- Conclusions
- Two SNPs, rs1042718 (C/A) and rs1042719 (G/C), of ADRB2 in linkage disequilibrium were found to be associated with enhanced longevity in men in two geographically isolated populations. Men with haplotype A-C showed an increased probability to become centenarians , in contrast to those with haplotype C-G.
Variants (2)
1.
- Identifier
- rs1042718
- Cytogenetic Location
- 5q32
- UCSC Genome Browser
- View 5q32 on the UCSC genome browser
2.
- Identifier
- rs1042719
- Cytogenetic Location
- 5q32
- UCSC Genome Browser
- View 5q32 on the UCSC genome browser
Gene details
- HGNC symbol
- ADRB2
- Aliases
- BAR; B2AR; ADRBR; ADRB2R; BETA2AR
- Common name
- adrenoceptor beta 2
- Description
- This gene encodes beta-2-adrenergic receptor which is a member of the G protein-coupled receptor superfamily. This receptor is directly associated with one of its ultimate effectors, the class C L-type calcium channel Ca(V)1.2. This receptor-channel complex also contains a G protein, an adenylyl cyclase, cAMP-dependent kinase, and the counterbalancing phosphatase, PP2A. The assembly of the signaling complex provides a mechanism that ensures specific and rapid signaling by this G protein-coupled receptor. This gene is intronless. Different polymorphic forms, point mutations, and/or downregulation of this gene are associated with nocturnal asthma, obesity and type 2 diabetes. [provided by RefSeq, Jul 2008]
- Other longevity studies of this gene
- 6
- OMIM
- 109690
- Ensembl
- ENSG00000169252
- UniProt/Swiss-Prot
- ADRB2_HUMAN
- Entrez Gene
- 154
- UniGene
- 2551
- HapMap
- View on HapMap