LongevityMap variant
Entry Details
- Longevity Association
- Significant
- Population
- Italian (Southern)
- Study Design
- Using a tagging approach, the possible associations between longevity and the common genetic variation at the three bitter taste receptor gene clusters on chromosomes 5, 7 and 12 in a population of 941 unrelated individuals (20-106 years old) was investigated. The study included 348 very elderly cases (>=85 years, mean age 93.82 years, median age 92) and 593 non-elderly controls (<85 years, mean age 59.17 years, median age 67 years).
- Conclusions
- One of the analyzed polymorphism, rs978739, situated upstream of the TAS2R16 gene, shows a statistically significant association with longevity. The frequency of A/A homozygotes increases gradually from 35% in subjects aged 20 to 70 up to 55% in centenarians.
- Identifier
- rs978739
- Cytogenetic Location
- 7q31.32
- UCSC Genome Browser
- View 7q31.32 on the UCSC genome browser
Gene details
- HGNC symbol
- TAS2R16
- Aliases
- T2R16
- Common name
- taste 2 receptor member 16
- Description
- This gene encodes a member of a family of candidate taste receptors that are members of the G protein-coupled receptor superfamily. These family members are specifically expressed by taste receptor cells of the tongue and palate epithelia. Each of these apparently intronless genes encodes a 7-transmembrane receptor protein, functioning as a bitter taste receptor. This gene is clustered with another 3 candidate taste receptor genes in chromosome 7 and is genetically linked to loci that influence bitter perception. [provided by RefSeq, Jul 2008]
- Other longevity studies of this gene
- 3
- OMIM
- 604867
- Ensembl
- ENSG00000128519
- UniProt/Swiss-Prot
- T2R16_HUMAN
- Entrez Gene
- 50833
- UniGene
- 272395
- HapMap
- View on HapMap