LongevityMap variant
- Longevity Association
- Significant
- Population
- French
- Study Design
- Polymorphism at codon 192 (Gln/Arg) was examined in 256 healthy Caucasian men (69.8 +/- 4.0 years)
- Conclusions
- Gln homozygotes are more frequent in aging than Arg allele carriers
- HGNC symbol
- PON1
- Aliases
- ESA; PON; MVCD5
- Common name
- paraoxonase 1
- Description
- The enzyme encoded by this gene is an arylesterase that mainly hydrolyzes paroxon to produce p-nitrophenol. Paroxon is an organophosphorus anticholinesterase compound that is produced in vivo by oxidation of the insecticide parathion. Polymorphisms in this gene are a risk factor in coronary artery disease. The gene is found in a cluster of three related paraoxonase genes at 7q21.3. [provided by RefSeq, Oct 2008]
- Other longevity studies of this gene
- 31
- OMIM
- 168820
- Ensembl
- ENSG00000005421
- UniProt/Swiss-Prot
- PON1_HUMAN
- Entrez Gene
- 5444
- UniGene
- 370995
- HapMap
- View on HapMap
Homologs in model organisms
- Caenorhabditis elegans
- poml-4
- Caenorhabditis elegans
- mec-6
- Caenorhabditis elegans
- poml-2
- Caenorhabditis elegans
- poml-3
- Danio rerio
- pon3.2
- Danio rerio
- pon3.2
- Danio rerio
- pon2
- Danio rerio
- pon1
- Mus musculus
- Pon1
- Rattus norvegicus
- Pon1
- GenAge human genes
- This gene is present as PON1
- CellAge
- This gene is present as PON1
Xia et al. (2003)
Other variants which are also part of this study
