LongevityMap variant
Entry Details
- Longevity Association
- Non-significant
- Population
- Danish
- Study Design
- 592 SNPs from 77 genes involved in nine sub-processes were analyzed in 1089 long-lived and 736 middle-aged Danes. Then, a replicated study was carried out in a German cohort.
- Conclusions
- The results did not remain significant after correction. The findings drawn from the Danish cohort were not replicated in German samples.
- Identifier
- rs1805329
- In Other Studies (IDs)
- 265
- Cytogenetic Location
- 9q31.2
- UCSC Genome Browser
- View 9q31.2 on the UCSC genome browser
Gene details
- HGNC symbol
- RAD23B
- Aliases
- P58; HR23B; HHR23B
- Common name
- RAD23 homolog B, nucleotide excision repair protein
- Description
- The protein encoded by this gene is one of two human homologs of Saccharomyces cerevisiae Rad23, a protein involved in the nucleotide excision repair (NER). This protein was found to be a component of the protein complex that specifically complements the NER defect of xeroderma pigmentosum group C (XP-c) cell extracts in vitro. This protein was also shown to interact with, and elevate the nucleotide excision activity of 3-methyladenine-DNA glycosylase (MPG), which suggested a role in DNA damage recognition in base excision repair. This protein contains an N-terminal ubiquitin-like domain, which was reported to interact with 26S proteasome, and thus this protein may be involved in the ubiquitin mediated proteolytic pathway in cells. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Sep 2011]
- Other longevity studies of this gene
- 13
- OMIM
- 600062
- Ensembl
- ENSG00000119318
- UniProt/Swiss-Prot
- B7Z4W4_HUMAN
- Entrez Gene
- 5887
- UniGene
- 521640
- HapMap
- View on HapMap
Homologs in model organisms
- Caenorhabditis elegans
- rad-23
- Danio rerio
- rad23b
- Drosophila melanogaster
- Rad23
- Mus musculus
- Rad23b
- Rattus norvegicus
- Rad23b
- Saccharomyces cerevisiae
- RAD23