LongevityMap variant
Entry Details
- Longevity Association
- Non-significant
- Population
- Danish
- Study Design
- 592 SNPs from 77 genes involved in nine sub-processes were analyzed in 1089 long-lived and 736 middle-aged Danes. Then, a replicated study was carried out in a German cohort.
- Conclusions
- The results did not remain significant after correction. The findings drawn from the Danish cohort were not replicated in German samples.
- Identifier
- rs4149965
- In Other Studies (IDs)
- 475
- Cytogenetic Location
- 1q43
- UCSC Genome Browser
- View 1q43 on the UCSC genome browser
Gene details
- HGNC symbol
- EXO1
- Aliases
- HEX1; hExoI
- Common name
- exonuclease 1
- Description
- This gene encodes a protein with 5' to 3' exonuclease activity as well as an RNase H activity. It is similar to the Saccharomyces cerevisiae protein Exo1 which interacts with Msh2 and which is involved in mismatch repair and recombination. Alternative splicing of this gene results in three transcript variants encoding two different isoforms. [provided by RefSeq, Jul 2008]
- Other longevity studies of this gene
- 20
- OMIM
- 606063
- Ensembl
- ENSG00000174371
- UniProt/Swiss-Prot
- A8K5H6_HUMAN
- Entrez Gene
- 9156
- UniGene
- 498248
- HapMap
- View on HapMap
Homologs in model organisms
- Caenorhabditis elegans
- exo-1
- Danio rerio
- exo1
- Drosophila melanogaster
- tos
- Mus musculus
- Exo1
- Rattus norvegicus
- Exo1
- Saccharomyces cerevisiae
- EXO1
- Saccharomyces cerevisiae
- DIN7