LongevityMap variant
Entry Details
- Longevity Association
- Significant
- Population
- Danish
- Study Design
- Alleles in candidate pathways (GH/IGF1 signaling, DNA damage signaling and repair and pro/antioxidants) were investigated for association with longevity in 1089 oldest-old (age 92-93) and 736 middle-aged Danes
- Conclusions
- Eleven SNPs (in GSR, KL, GHRHR, INS, GHSR, IGF2R, RAD52, WRN, RAD23B, POLB and NTLH1) were associated with longevity after correction for multiple hypothesis testing. No replications were observed in German and Dutch populations.
- Identifier
- rs2953983
- In Other Studies (IDs)
- 3199
- Cytogenetic Location
- 8p11.21
- UCSC Genome Browser
- View 8p11.21 on the UCSC genome browser
Gene details
- HGNC symbol
- POLB
- Aliases
- Common name
- DNA polymerase beta
- Description
- The protein encoded by this gene is a DNA polymerase involved in base excision and repair, also called gap-filling DNA synthesis. The encoded protein, acting as a monomer, is normally found in the cytoplasm, but it translocates to the nucleus upon DNA damage. Several transcript variants of this gene exist, but the full-length nature of only one has been described to date. [provided by RefSeq, Sep 2011]
- Other longevity studies of this gene
- 3
- OMIM
- 174760
- Ensembl
- ENSG00000070501
- UniProt/Swiss-Prot
- B7Z1W5_HUMAN
- Entrez Gene
- 5423
- UniGene
- 654484
- HapMap
- View on HapMap
Homologs in model organisms
In other databases
- GenAge human genes
- This gene is present as POLB