GenAge entry for EIF5A2 (Homo sapiens)
Entry selected based on evidence directly linking the gene product to ageing in a mammalian model organism
Gene name (HAGRID: 289)
- HGNC symbol
- EIF5A2
- Aliases
- Common name
- eukaryotic translation initiation factor 5A2
Potential relevance to the human ageing process
- Main reason for selection
- Entry selected based on evidence directly linking the gene product to ageing in a mammalian model organism
- Description
A highly conserved gene involved in in translation elongation, EIF5A2 has been associated with cancer [3403]. Its overexpression in mice results in accumulation of chromosomal instability and features resembling accelerated ageing, including a short lifespan, kyphosis, osteoporosis, delay of wound healing and ossification [3246]. Although further studies are needed, EIF5A2 might then play a role in human ageing.
Cytogenetic information
- Cytogenetic band
- 3q26.2
- Location
- 170,888,415 bp to 170,908,637 bp
- Orientation
- Minus strand
Protein information
- Gene Ontology
-
Process: GO:0006452; translational frameshifting
GO:0007283; spermatogenesis
GO:0008284; positive regulation of cell proliferation
GO:0008612; peptidyl-lysine modification to peptidyl-hypusine
GO:0010509; polyamine homeostasis
GO:0015031; protein transport
GO:0045901; positive regulation of translational elongation
GO:0045905; positive regulation of translational termination
GO:0051028; mRNA transport
Cellular component: GO:0005643; nuclear pore
GO:0005789; endoplasmic reticulum membrane
GO:0005829; cytosol
GO:0043231; intracellular membrane-bounded organelle
Function: GO:0003746; translation elongation factor activity
GO:0005515; protein binding
GO:0043022; ribosome binding
Protein interactions and network
No interactions in records.
Retrieve sequences for EIF5A2
Homologs in model organisms
- Danio rerio
- eif5a
- Drosophila melanogaster
- eIF-5A
- Mus musculus
- Eif5a2
- Rattus norvegicus
- Eif5a2
- Saccharomyces cerevisiae
- HYP2
- Schizosaccharomyces pombe
- tif51b
In other databases
- GenAge model organism genes
- A homolog of this gene for Mus musculus is present as Eif5a2
Selected references
External links
- EPD
- ORF Accession
- NM_020390
- CDS Accession
- NP_065123
- OMIM
- 605782
- HPRD
- 10426
- Ensembl
- EIF5A2
- UniProt/Swiss-Prot
- IF5A2_HUMAN
- GeneCards
- EIF5A2
- Entrez Gene
- 56648
- GenAtlas
- EIF5A2
- Internet
- Search Google