GenAge entry for UCP3 (Homo sapiens)
Gene name (HAGRID: 232)
- HGNC symbol
- UCP3
- Aliases
- SLC25A9
- Common name
- uncoupling protein 3 (mitochondrial, proton carrier)
Potential relevance to the human ageing process
- Main reason for selection
- Entry selected based on evidence linking the gene product to a pathway or mechanism linked to ageing
- Description
Mitochondrial uncoupling proteins create proton leaks across the inner mitochondrial membrane to uncouple oxidative phosphorylation from ATP synthesis resulting in energy being dissipated as heat. UCP3, whose gene has two splice variants, appears thus to be involved in thermogenesis. Some results from mice suggest that UCP3 might protect against oxidative damage [1449]. Mice overexpressing UCP3 in skeletal muscle are hyperphagic and lean [1456]. UCP3-null mice were normal, though production of reactive oxygen species was increased in mitochondria [1458]. Polymorphisms in the human UCP3 gene could be related to obesity and type 2 diabetes [1459].
Cytogenetic information
- Cytogenetic band
- 11q13.4
- Location
- 74,000,281 bp to 74,009,237 bp
- Orientation
- Minus strand
Protein information
- Gene Ontology
-
Process: GO:0000303; response to superoxide
GO:0001666; response to hypoxia
GO:0006629; lipid metabolic process
GO:0006631; fatty acid metabolic process
GO:0006839; mitochondrial transport
GO:0007568; aging
GO:0007584; response to nutrient
GO:0007585; respiratory gaseous exchange
GO:0009409; response to cold
GO:0014823; response to activity
GO:0015992; proton transport
And 4 more GO terms Cellular component: GO:0005739; mitochondrion
GO:0005743; mitochondrial inner membrane
GO:0016021; integral component of membrane
Function: GO:0005215; transporter activity
GO:0005515; protein binding
GO:0017077; oxidative phosphorylation uncoupler activity
Protein interactions and network
Retrieve sequences for UCP3
Homologs in model organisms
In other databases
- LongevityMap
- This gene is present as UCP3
Selected references
External links
- EPD
- ORF Accession
- NM_003356
- CDS Accession
- NP_003347
- OMIM
- 602044
- HPRD
- 03623
- Ensembl
- UCP3
- UniProt/Swiss-Prot
- UCP3_HUMAN
- GeneCards
- UCP3
- Entrez Gene
- 7352
- GenAtlas
- UCP3
- Internet
- Search Google