GenAge entry for SUN1 (Homo sapiens)
Gene name (HAGRID: 277)
- HGNC symbol
- SUN1
- Aliases
- KIAA0810; FLJ12407; UNC84A
- Common name
- Sad1 and UNC84 domain containing 1
Potential relevance to the human ageing process
- Main reason for selection
- Entry selected based on evidence linking the gene product to the regulation or control of genes previously linked to ageing
- Description
Mutations in the LMNA gene result in Hutchinson-Gilford progeroid syndrome. Two mouse models, Lmna null (Lmna(-/-)) and progeroid Lmna delta9 have been created, displaying these two pathologies, with an accordingly shorten lifespan. In both cases, however, a deficiency in the Sun1 gene resulted in reduced tissue pathologies and enhanced longevity. Similarly, a reduction of SUN1 overaccumulation in LMNA mutant fibroblasts and in cells derived from progeroid patients corrected nuclear defects and cellular senescence [2197]. Further studies are warranted.
Cytogenetic information
- Cytogenetic band
- 7p22.3
- Location
- 816,615 bp to 874,920 bp
- Orientation
- Plus strand
Protein information
- Gene Ontology
-
Process: GO:0001503; ossification
GO:0006998; nuclear envelope organization
GO:0007129; synapsis
GO:0009612; response to mechanical stimulus
GO:0021817; nucleokinesis involved in cell motility in cerebral cortex radial glia guided migration
GO:0051642; centrosome localization
GO:0070197; meiotic attachment of telomere to nuclear envelope
GO:0090286; cytoskeletal anchoring at nuclear membrane
GO:0090292; nuclear matrix anchoring at nuclear membrane
Cellular component: GO:0002080; acrosomal membrane
GO:0005635; nuclear envelope
GO:0005639; integral component of nuclear inner membrane
GO:0031965; nuclear membrane
GO:0034993; LINC complex
GO:0043231; intracellular membrane-bounded organelle
Function: GO:0005515; protein binding
GO:0005521; lamin binding
Protein interactions and network
No interactions in records.
Retrieve sequences for SUN1
Homologs in model organisms
- Caenorhabditis elegans
- unc-84
- Danio rerio
- sun1
- Drosophila melanogaster
- koi
- Mus musculus
- Sun1
- Rattus norvegicus
- Sun1
Selected references
External links
- EPD
- ORF Accession
- NM_001171944
- CDS Accession
- NP_001165415
- OMIM
- 607723
- HPRD
- 16257
- Ensembl
- SUN1
- UniProt/Swiss-Prot
- SUN1_HUMAN
- GeneCards
- SUN1
- Entrez Gene
- 23353
- GenAtlas
- SUN1
- Internet
- Search Google