GenAge entry for NUDT1 (Homo sapiens)
Entry selected based on evidence directly linking the gene product to ageing in a mammalian model organism
Gene name (HAGRID: 296)
- HGNC symbol
- NUDT1
- Aliases
- MTH1
- Common name
- nudix (nucleoside diphosphate linked moiety X)-type motif 1
Potential relevance to the human ageing process
- Main reason for selection
- Entry selected based on evidence directly linking the gene product to ageing in a mammalian model organism
- Description
NUDT1 degrades oxidative damage to DNA and RNA. Mice defective in NUDT1 develop spontaneous tumours [3430]. Mice overexpressing human NUDT1 have lower levels of DNA damage and live 16% longer [3257], suggesting a role in ageing. Further studies are necessary, however.
Cytogenetic information
- Cytogenetic band
- 7p22
- Location
- 2,242,221 bp to 2,251,145 bp
- Orientation
- Plus strand
Protein information
- Gene Ontology
-
Process: GO:0006195; purine nucleotide catabolic process
GO:0006203; dGTP catabolic process
GO:0006281; DNA repair
GO:0006979; response to oxidative stress
GO:0007568; aging
GO:0008584; male gonad development
GO:0034656; nucleobase-containing small molecule catabolic process
GO:0042262; DNA protection
GO:0046061; dATP catabolic process
GO:0046686; response to cadmium ion
Cellular component: GO:0001669; acrosomal vesicle
GO:0005615; extracellular space
GO:0005634; nucleus
GO:0005737; cytoplasm
GO:0005739; mitochondrion
GO:0005759; mitochondrial matrix
GO:0005829; cytosol
GO:0005886; plasma membrane
GO:0031965; nuclear membrane
GO:0070062; extracellular exosome
Function: GO:0003924; GTPase activity
GO:0005515; protein binding
GO:0008413; 8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity
GO:0030515; snoRNA binding
GO:0035539; 8-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity
GO:0036219; GTP diphosphatase activity
GO:0044713; 2-hydroxy-adenosine triphosphate pyrophosphatase activity
GO:0044714; 2-hydroxy-(deoxy)adenosine-triphosphate pyrophosphatase activity
GO:0046872; metal ion binding
GO:0047693; ATP diphosphatase activity
GO:0050072; m7G(5')pppN diphosphatase activity
And 1 more GO terms
Protein interactions and network
No interactions in records.
Retrieve sequences for NUDT1
Homologs in model organisms
In other databases
- GenAge model organism genes
- A homolog of this gene for Mus musculus is present as NUDT1
- CellAge gene expression
- This gene is present as NUDT1
Selected references
External links
- EPD
- ORF Accession
- NM_002452
- CDS Accession
- NP_002443
- OMIM
- 600312
- HPRD
- 02634
- Ensembl
- NUDT1
- UniProt/Swiss-Prot
- 8ODP_HUMAN
- GeneCards
- NUDT1
- Entrez Gene
- 4521
- GenAtlas
- NUDT1
- Internet
- Search Google