GenAge entry for ERCC5 (Homo sapiens)
Gene name (HAGRID: 109)
- HGNC symbol
- ERCC5
- Aliases
- ERCM2; XPGC
- Common name
- excision repair cross-complementation group 5
Potential relevance to the human ageing process
- Main reason for selection
- Entry selected based on evidence linking the gene product to a pathway or mechanism linked to ageing
- Description
Due to its role in DNA repair in association with the other ERCC proteins, it is possible ERCC5 plays a role in human ageing. Mutations in human ERCC5 cause Xeroderma pigmentosum group G [570], but have also been associated with features of Cockayne syndrome [569].
Cytogenetic information
- Cytogenetic band
- 13q33
- Location
- 102,845,841 bp to 102,876,001 bp
- Orientation
- Plus strand
Protein information
- Gene Ontology
-
Process: GO:0006283; transcription-coupled nucleotide-excision repair
GO:0006293; nucleotide-excision repair, preincision complex stabilization
GO:0006294; nucleotide-excision repair, preincision complex assembly
GO:0006295; nucleotide-excision repair, DNA incision, 3'-to lesion
GO:0006296; nucleotide-excision repair, DNA incision, 5'-to lesion
GO:0009411; response to UV
GO:0009650; UV protection
GO:0010225; response to UV-C
GO:0033683; nucleotide-excision repair, DNA incision
GO:0043066; negative regulation of apoptotic process
Cellular component: GO:0005634; nucleus
GO:0005654; nucleoplasm
GO:0005662; DNA replication factor A complex
GO:0005675; holo TFIIH complex
GO:0016591; DNA-directed RNA polymerase II, holoenzyme
Function: GO:0000405; bubble DNA binding
GO:0003690; double-stranded DNA binding
GO:0003697; single-stranded DNA binding
GO:0004520; endodeoxyribonuclease activity
GO:0005515; protein binding
GO:0042803; protein homodimerization activity
GO:0046872; metal ion binding
GO:0047485; protein N-terminus binding
Protein interactions and network
- Protein-protein interacting partners in GenAge
- ERCC2, ERCC6, ERCC3, PCNA, CDK7
- STRING interaction network
Retrieve sequences for ERCC5
Homologs in model organisms
- Caenorhabditis elegans
- xpg-1
- Caenorhabditis elegans
- gen-1
- Danio rerio
- ercc5
- Drosophila melanogaster
- mus201
- Mus musculus
- Ercc5
- Rattus norvegicus
- Ercc5
- Saccharomyces cerevisiae
- RAD2
- Schizosaccharomyces pombe
- rad13
In other databases
- LongevityMap
- This gene is present as ERCC5
Selected references
External links
- EPD
- ORF Accession
- NM_000123
- CDS Accession
- NP_000114
- OMIM
- 133530
- HPRD
- 00595
- Ensembl
- ERCC5
- UniProt/Swiss-Prot
- ERCC5_HUMAN
- GeneCards
- ERCC5
- Entrez Gene
- 2073
- GenAtlas
- ERCC5
- Internet
- Search Google