GenAge entry for ERCC5 (Homo sapiens)

Gene name (HAGRID: 109)

HGNC symbol
ERCC5 
Aliases
ERCM2; XPGC 
Common name
excision repair cross-complementation group 5 

Potential relevance to the human ageing process

Main reason for selection
Entry selected based on evidence linking the gene product to a pathway or mechanism linked to ageing
Description

Due to its role in DNA repair in association with the other ERCC proteins, it is possible ERCC5 plays a role in human ageing. Mutations in human ERCC5 cause Xeroderma pigmentosum group G [570], but have also been associated with features of Cockayne syndrome [569].

Cytogenetic information

Cytogenetic band
13q33
Location
102,845,841 bp to 102,876,001 bp
Orientation
Plus strand
Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology
Process: GO:0006283; transcription-coupled nucleotide-excision repair
GO:0006293; nucleotide-excision repair, preincision complex stabilization
GO:0006294; nucleotide-excision repair, preincision complex assembly
GO:0006295; nucleotide-excision repair, DNA incision, 3'-to lesion
GO:0006296; nucleotide-excision repair, DNA incision, 5'-to lesion
GO:0009411; response to UV
GO:0009650; UV protection
GO:0010225; response to UV-C
GO:0033683; nucleotide-excision repair, DNA incision
GO:0043066; negative regulation of apoptotic process
Cellular component: GO:0005634; nucleus
GO:0005654; nucleoplasm
GO:0005662; DNA replication factor A complex
GO:0005675; holo TFIIH complex
GO:0016591; DNA-directed RNA polymerase II, holoenzyme
Function: GO:0000405; bubble DNA binding
GO:0003690; double-stranded DNA binding
GO:0003697; single-stranded DNA binding
GO:0004520; endodeoxyribonuclease activity
GO:0005515; protein binding
GO:0042803; protein homodimerization activity
GO:0046872; metal ion binding
GO:0047485; protein N-terminus binding
Show all GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge
ERCC2, ERCC6, ERCC3, PCNA, CDK7
STRING interaction network
Protein-Protein network diagram for ERCC5

Retrieve sequences for ERCC5

ORF
ORF
CDS
CDS

Homologs in model organisms

Caenorhabditis elegans
xpg-1
Caenorhabditis elegans
gen-1
Danio rerio
ercc5
Drosophila melanogaster
mus201
Mus musculus
Ercc5
Rattus norvegicus
Ercc5
Saccharomyces cerevisiae
RAD2
Schizosaccharomyces pombe
rad13

In other databases

LongevityMap
  • This gene is present as ERCC5

Selected references

External links

EPD
ORF Accession
NM_000123
CDS Accession
NP_000114
OMIM
133530
HPRD
00595
Ensembl
ERCC5
UniProt/Swiss-Prot
ERCC5_HUMAN
GeneCards
ERCC5
Entrez Gene
2073
GenAtlas
ERCC5
Internet
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