GenAge entry for SUN1 (Homo sapiens)

Gene name (HAGRID: 277)

HGNC symbol: SUN1
Aliases: KIAA0810; FLJ12407; UNC84A
Common name: Sad1 and UNC84 domain containing 1

Potential relevance to the human ageing process

Main reason for selection: Entry selected based on evidence linking the gene product to the regulation or control of genes previously linked to ageing
Description: Mutations in the LMNA gene result in Hutchinson-Gilford progeroid syndrome. Two mouse models, Lmna null (Lmna(-/-)) and progeroid Lmna delta9 have been created, displaying these two pathologies, with an accordingly shorten lifespan. In both cases, however, a deficiency in the Sun1 gene resulted in reduced tissue pathologies and enhanced longevity. Similarly, a reduction of SUN1 overaccumulation in LMNA mutant fibroblasts and in cells derived from progeroid patients corrected nuclear defects and cellular senescence [2197]. Further studies are warranted.

Cytogenetic information

Cytogenetic band: 7p22.3
Location: 816,615 bp to 874,920 bp
Orientation: Plus strand

Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology

Process:

GO:0001503; ossification
GO:0006998; nuclear envelope organization
GO:0007129; synapsis
GO:0009612; response to mechanical stimulus
GO:0021817; nucleokinesis involved in cell motility in cerebral cortex radial glia guided migration
GO:0051642; centrosome localization
GO:0070197; meiotic attachment of telomere to nuclear envelope
GO:0090286; cytoskeletal anchoring at nuclear membrane
GO:0090292; nuclear matrix anchoring at nuclear membrane

Cellular component:

GO:0002080; acrosomal membrane
GO:0005635; nuclear envelope
GO:0005639; integral component of nuclear inner membrane
GO:0031965; nuclear membrane
GO:0034993; LINC complex
GO:0043231; intracellular membrane-bounded organelle

Function:

GO:0005515; protein binding
GO:0005521; lamin binding

Hide GO terms

Protein interactions and network

No interactions in records.

Retrieve sequences for SUN1

ORF: ORF
CDS: CDS

Homologs in model organisms

Caenorhabditis elegans: unc-84
Danio rerio: sun1
Drosophila melanogaster: koi
Mus musculus: Sun1
Rattus norvegicus: Sun1