GenAge entry for PON1 (Homo sapiens)

Gene name (HAGRID: 142)

HGNC symbol: PON1
Aliases: ESA; PON
Common name: paraoxonase 1

Potential relevance to the human ageing process

Main reason for selection: Entry selected based on indirect or inconclusive evidence linking the gene product to ageing in humans or in one or more model systems
Description: PON1 hydrolyzes toxic compounds and is associated with high-density lipoproteins. Mice without PON1 are more susceptible to some toxic agents and, when fed a high-fat, high-cholesterol diet, display atherosclerosis [708]. Allelic variants in the human PON1 gene have been linked to longevity [706] and neurodegenerative diseases [707]. A role in human ageing is possible even if unverified.

Cytogenetic information

Cytogenetic band: 7q21.3
Location: 95,298,357 bp to 95,324,572 bp
Orientation: Minus strand

Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology

Process:

GO:0008203; cholesterol metabolic process
GO:0009605; response to external stimulus
GO:0009636; response to toxic substance
GO:0010875; positive regulation of cholesterol efflux
GO:0016311; dephosphorylation
GO:0019439; aromatic compound catabolic process
GO:0031667; response to nutrient levels
GO:0032411; positive regulation of transporter activity
GO:0034445; negative regulation of plasma lipoprotein particle oxidation
GO:0046395; carboxylic acid catabolic process
GO:0046434; organophosphate catabolic process
GO:0046470; phosphatidylcholine metabolic process
GO:0051099; positive regulation of binding
GO:0070542; response to fatty acid
GO:1902617; response to fluoride

Cellular component:

GO:0005576; extracellular region
GO:0005615; extracellular space
GO:0034364; high-density lipoprotein particle
GO:0034366; spherical high-density lipoprotein particle
GO:0043231; intracellular membrane-bounded organelle
GO:0070062; extracellular exosome
GO:0072562; blood microparticle

Function:

GO:0004063; aryldialkylphosphatase activity
GO:0004064; arylesterase activity
GO:0005509; calcium ion binding
GO:0005543; phospholipid binding
GO:0042803; protein homodimerization activity
GO:0102007; acyl-L-homoserine-lactone lactonohydrolase activity

Hide GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge: CLU
STRING interaction network

Retrieve sequences for PON1

ORF: ORF
CDS: CDS

Homologs in model organisms

Caenorhabditis elegans: poml-4
Caenorhabditis elegans: mec-6
Caenorhabditis elegans: poml-2
Caenorhabditis elegans: poml-3
Danio rerio: pon3.2
Danio rerio: pon3.2
Danio rerio: pon2
Danio rerio: pon1
Mus musculus: Pon1
Rattus norvegicus: Pon1

In other databases

LongevityMap

This gene is present as PON1

CellAge

This gene is present as PON1