- Symbol
- Ucp2
- Aliases
- Slc25a8
- Name
- uncoupling protein 2 (mitochondrial, proton carrier)
- Organism
- Mus musculus (AnAge)
- Known functions and activities
- Mitochondrial uncoupling proteins create proton leaks across the inner mitochondrial membrane to uncouple oxidative phosphorylation from ATP synthesis
- Observations
- Overexpression in hypocretin neurons results in mice with elevated hypothalamic temperature and reduction of core body temperature and a 12% increase in median lifespan in males and 20% increase in females.
- % change in avg or median lifespan
- Median male lifespan is 12% higher; Median female lifespan is 20% higher.
- Lifespan Effect
- Increase
- Genetic Manipulation
- Overexpression
- Longevity Category
- Pro-Longevity
- Primary reference
-
- GenAge model organism genes
- A homolog of this gene for Drosophila melanogaster is present as UCP2
- GenAge human genes
- A homolog of this gene for Homo sapiens is present as UCP2
- GenDR gene manipulations
- A homolog of this gene for Caenorhabditis elegans is present as ucp2
- LongevityMap
- A homolog of this gene for Homo sapiens is present as UCP2
- Danio rerio
- ucp2
- Homo sapiens
- UCP2
- Rattus norvegicus
- Ucp2
- Saccharomyces cerevisiae
- DIC1
- Mouse Genome Informatics
- Search
- Ensembl
- Search
- Entrez Gene
- View on Entrez Gene database (22228)
- Homologues
- Search HomoloGene
- UniProt
- Search
- Internet
- Search Google or Search Google Scholar
GenAge entry for Ucp2 (Mus musculus)