GenAge entry for Tert (Mus musculus)
Gene information (ID: 672)
- Symbol
- Tert
- Aliases
- TR; TP2; TRT; EST2; TCS1
- Name
- Telomerase reverse transcriptase
- Organism
- Mus musculus (AnAge)
- Known functions and activities
- Telomere elongation
Potential relevance to longevity and/or ageing
- Observations
- Overexpression of telomerase results in a high cancer incidence but also a modest lifespan extension accompanied by a lower incidence of some age-related degenerative diseases, in particular those related to kidney function and germline integrity.
- Lifespan Effect
- Increase
- Genetic Manipulation
- Overexpression
- Longevity Category
- Pro-Longevity
- Primary reference
-
- Observations
- 9% up to 50% extension of the median lifespan, when overexpressed in mice engineered to be cancer resistant by means of enhanced expression of the tumor suppressors p53, p16, andp19ARF.
- % change in max lifespan
- Maximum lifespan is 9-50% higher.
- Lifespan Effect
- Increase
- Genetic Manipulation
- Overexpression
- Longevity Category
- Pro-Longevity
- Primary reference
-
- Observations
- Telomerase reactivation in late generation TERT-ER mice extends telomeres, reduces DNA damage signalling and associated cellular checkpoint responses, allows resumption of proliferation in quiescent cultures, and eliminates degenerative phenotypes across multiple organs including testes, spleens and intestines.
- Lifespan Effect
- Increase
- Genetic Manipulation
- Knockin
- Longevity Category
- Pro-Longevity
- Primary reference
-
In other databases
- GenAge model organism genes
- A homolog of this gene for Danio rerio is present as tert
- GenAge human genes
- A homolog of this gene for Homo sapiens is present as TERT
- LongevityMap
- A homolog of this gene for Homo sapiens is present as TERT
- CellAge
- A homolog of this gene for Homo sapiens is present as TERT
Homologs in other organisms
- Danio rerio
- tert
- Homo sapiens
- TERT
- Rattus norvegicus
- Tert
- Saccharomyces cerevisiae
- EST2
- Schizosaccharomyces pombe
- trt1
External links
- Mouse Genome Informatics
- Search
- Ensembl
- Search
- Entrez Gene
- View on Entrez Gene database (21752)
- Homologues
- Search HomoloGene
- UniProt
- Search
- Internet
- Search Google or Search Google Scholar