Cell Senescence Entries for AGR2

Cell Types
Prostate cancer
Cell Lines
DU145, LNCaP, PC-3
Cancer Cell?
Yes
Method
Knockdown
Type of senescence
Oncogene-induced
Senescence Effect
Inhibits
Primary Reference
Hu et al. (2012) Knockdown of AGR2 induces cellular senescence in prostate cancer cells. Carcinogenesis 33(6)1178-86 (PubMed)

AGR2 Gene Information

HGNC symbol
AGR2 
Aliases
AG2; HAG-2; PDIA17; XAG-2 
Common name
anterior gradient 2, protein disulphide isomerase family member 
Entrez Id
10551
Description
This gene encodes a member of the disulfide isomerase (PDI) family of endoplasmic reticulum (ER) proteins that catalyze protein folding and thiol-disulfide interchange reactions. The encoded protein has an N-terminal ER-signal sequence, a catalytically active thioredoxin domain, and a C-terminal ER-retention sequence. This protein plays a role in cell migration, cellular transformation and metastasis and is as a p53 inhibitor. As an ER-localized molecular chaperone, it plays a role in the folding, trafficking, and assembly of cysteine-rich transmembrane receptors and the cysteine-rich intestinal gylcoprotein mucin. This gene has been implicated in inflammatory bowel disease and cancer progression. [provided by RefSeq, Mar 2017].

AGR2 Ontologies

Gene Ontology
Process: GO:48546; digestive tract morphogenesis
GO:10628; positive regulation of gene expression
GO:60548; negative regulation of cell death
GO:1903078; positive regulation of protein localization to plasma membrane
GO:45742; positive regulation of epidermal growth factor receptor signaling pathway
GO:10811; positive regulation of cell-substrate adhesion
GO:48639; positive regulation of developmental growth
GO:60480; lung goblet cell differentiation
GO:70254; mucus secretion
GO:1903896; positive regulation of IRE1-mediated unfolded protein response
GO:1903899; positive regulation of PERK-mediated unfolded protein response
And 1 more GO terms
Cellular component: GO:5783; endoplasmic reticulum
GO:5576; extracellular region
GO:5615; extracellular space
Function: GO:42802; identical protein binding
GO:5515; protein binding
GO:2162; dystroglycan binding
GO:5154; epidermal growth factor receptor binding
Show all GO terms

Homologs of AGR2 in Model Organisms

Caenorhabditis elegans
Y57A10A.23
Caenorhabditis elegans
F49H12.5
Danio rerio
agr2
Mus musculus
Agr2
Rattus norvegicus
Agr2

External links

OMIM
606358
Ensembl
ENSG00000106541
Entrez Gene
10551
UniGene
530009
1000 Genomes
1000 Genomes
HPRD
GenAtlas
AGR2
GeneCards
AGR2