Cell Senescence Entries for RECQL4

Cell Types
Osteosarcoma
Cell Lines
U2OS
Cancer Cell?
Yes
Method
Knockdown, Mutation, Overexpression
Type of senescence
Unclear
Senescence Effect
Inhibits
Primary Reference
Lu et al. (2018) Cell cycle-dependent phosphorylation regulates RECQL4 pathway choice and ubiquitination in DNA double-strand break repair. Nat Commun 8(1)2039 (PubMed)

RECQL4 Gene Information

HGNC symbol
RECQL4 
Aliases
RecQ4 
Common name
RecQ like helicase 4 
Entrez Id
9401
Description
The protein encoded by this gene is a DNA helicase that belongs to the RecQ helicase family. DNA helicases unwind double-stranded DNA into single-stranded DNAs and may modulate chromosome segregation. This gene is predominantly expressed in thymus and testis. Mutations in this gene are associated with Rothmund-Thomson, RAPADILINO and Baller-Gerold syndromes. [provided by RefSeq, Jan 2010].

RECQL4 Ontologies

Gene Ontology
Process: GO:6310; DNA recombination
GO:6281; DNA repair
GO:724; double-strand break repair via homologous recombination
GO:723; telomere maintenance
GO:32508; DNA duplex unwinding
GO:6260; DNA replication
GO:6268; DNA unwinding involved in DNA replication
GO:61820; telomeric D-loop disassembly
Cellular component: GO:781; chromosome, telomeric region
GO:5634; nucleus
GO:5737; cytoplasm
GO:16020; membrane
GO:5654; nucleoplasm
GO:5694; chromosome
Function: GO:5515; protein binding
GO:3676; nucleic acid binding
GO:166; nucleotide binding
GO:5524; ATP binding
GO:16787; hydrolase activity
GO:4386; helicase activity
GO:16887; ATP hydrolysis activity
GO:3678; DNA helicase activity
GO:405; bubble DNA binding
GO:9378; four-way junction helicase activity
GO:32357; oxidized purine DNA binding
And 4 more GO terms
Show all GO terms

Homologs of RECQL4 in Model Organisms

Danio rerio
RECQL4
Drosophila melanogaster
RecQ4
Mus musculus
Recql4
Rattus norvegicus
Recql4
Saccharomyces cerevisiae
SGS1

In other databases

GenAge model organism genes
  • A homolog of this gene for Saccharomyces cerevisiae is present as SGS1
GenAge human genes
  • This gene is present as RECQL4
LongevityMap
  • This gene is present as RECQL4

External links

OMIM
603780
Ensembl
ENSG00000160957
Entrez Gene
9401
UniGene
31442
1000 Genomes
1000 Genomes
HPRD
GenAtlas
RECQL4
GeneCards
RECQL4