Cell Senescence Entries for KCNA1

Cell Types
Mammary epithelial
Cell Lines
Primary cell
Cancer Cell?
No
Method
Knockdown
Type of senescence
Oncogene-induced
Senescence Effect
Induces
Primary Reference
Lallet-Daher et al. (2014) Potassium channel KCNA1 modulates oncogene-induced senescence and transformation. Cancer Res 73(16)5253-65 (PubMed)

KCNA1 Gene Information

HGNC symbol
KCNA1 
Aliases
AEMK; HUK1; Kv1.1; MBK1; RBK1 
Common name
potassium voltage-gated channel subfamily A member 1 
Entrez Id
3736
Description
This gene encodes a voltage-gated delayed potassium channel that is phylogenetically related to the Drosophila Shaker channel. The encoded protein has six putative transmembrane segments (S1-S6), and the loop between S5 and S6 forms the pore and contains the conserved selectivity filter motif (GYGD). The functional channel is a homotetramer. The N-terminus of the channel is associated with beta subunits that can modify the inactivation properties of the channel as well as affect expression levels. The C-terminus of the channel is complexed to a PDZ domain protein that is responsible for channel targeting. Mutations in this gene have been associated with myokymia with periodic ataxia (AEMK). [provided by RefSeq, Jul 2008].

KCNA1 Ontologies

Gene Ontology
Process: GO:55085; transmembrane transport
GO:6811; ion transport
GO:6813; potassium ion transport
GO:34765; regulation of ion transmembrane transport
GO:51260; protein homooligomerization
GO:71805; potassium ion transmembrane transport
GO:99505; regulation of presynaptic membrane potential
GO:60078; regulation of postsynaptic membrane potential
GO:7268; chemical synaptic transmission
GO:42391; regulation of membrane potential
GO:50905; neuromuscular process
And 15 more GO terms
Cellular component: GO:16020; membrane
GO:16021; integral component of membrane
GO:31410; cytoplasmic vesicle
GO:5783; endoplasmic reticulum
GO:5886; plasma membrane
GO:5829; cytosol
GO:30054; cell junction
GO:42995; cell projection
GO:8076; voltage-gated potassium channel complex
GO:30425; dendrite
GO:45202; synapse
And 18 more GO terms
Function: GO:5216; ion channel activity
GO:5244; voltage-gated ion channel activity
GO:5249; voltage-gated potassium channel activity
GO:5267; potassium channel activity
GO:5515; protein binding
GO:5251; delayed rectifier potassium channel activity
GO:97718; disordered domain specific binding
GO:15079; potassium ion transmembrane transporter activity
GO:99508; voltage-gated ion channel activity involved in regulation of presynaptic membrane potential
GO:1905030; voltage-gated ion channel activity involved in regulation of postsynaptic membrane potential
Show all GO terms

Homologs of KCNA1 in Model Organisms

Caenorhabditis elegans
shk-1
Danio rerio
kcna1b
Danio rerio
kcna1a
Drosophila melanogaster
Sh
Mus musculus
Kcna1
Rattus norvegicus
Kcna1

In other databases

GenDR gene manipulations
  • A homolog of this gene for Caenorhabditis elegans is present as shk-1

External links

OMIM
176260
Ensembl
ENSG00000111262
Entrez Gene
3736
UniGene
416139
1000 Genomes
1000 Genomes
HPRD
GenAtlas
KCNA1
GeneCards
KCNA1