LongevityMap variant group
Entry Details
- Longevity Association
- Non-significant
- Population
- American (Caucasian and African-American)
- Study Design
- The baseline levels of sCD14 (soluble form of CD14) were measured in 5888 European-American and black adults aged 65 years and older from the Cardiovascular Health Study. A genome-wide cardiovascular disease candidate gene-centric association with sCD14 was conducted separately in the European-Americans (n=2952) and blacks (n=528). Finally, the ability of sCD14 and its main genetic determinants to predict incident CVD and mortality during follow-up was assessed.
- Conclusions
- sCD14 was positively correlated with cardio-metabolic risk factors and with subclinical measures of vascular disease, and was also inversely correlated with body mass index (all P<0.001). In European Americans the minor allele at the index SNP rs5744441 was associated with lower sCD14, the C allele of index SNP rs1063412 was associated with lower sCD14. In Blacks the index SNP rs778584 was associated with higher sCD14. In the fully adjusted model, sCD14 was associated with death because of cardiovascular causes (hazard ratio=1.13, P=0.001) and death because of noncardiovascular causes (hazard ratio=1.11, P=0.001). CD14 independently predicts risk mortality in older adults. However, no SNPs were associated with risk of mortality when corrected for multiple hypothesis testing.
Variants (10)
CD14
Gene details
- HGNC symbol
- CD14
- Aliases
- Common name
- CD14 molecule
- Description
- The protein encoded by this gene is a surface antigen that is preferentially expressed on monocytes/macrophages. It cooperates with other proteins to mediate the innate immune response to bacterial lipopolysaccharide. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Mar 2010]
- Other longevity studies of this gene
- 5
- OMIM
- 158120
- Ensembl
- ENSG00000170458
- UniProt/Swiss-Prot
- CD14_HUMAN
- Entrez Gene
- 929
- UniGene
- 163867
- HapMap
- View on HapMap
Homologs in model organisms
In other databases
- GenAge microarray genes
- This gene is present as CD14
DNM3
Gene details
- HGNC symbol
- DNM3
- Aliases
- Dyna; III
- Common name
- dynamin 3
- Description
- This gene encodes a member of a family of guanosine triphosphate (GTP)-binding proteins that associate with microtubules and are involved in vesicular transport. The encoded protein functions in the development of megakaryocytes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2013]
- OMIM
- 611445
- Ensembl
- ENSG00000197959
- UniProt/Swiss-Prot
- DYN3_HUMAN
- Entrez Gene
- 26052
- UniGene
- 654775
- HapMap
- View on HapMap
Homologs in model organisms
- Caenorhabditis elegans
- dyn-1
- Danio rerio
- dnm3a
- Danio rerio
- CABZ01092282.1
- Drosophila melanogaster
- shi
- Mus musculus
- Dnm3
- Rattus norvegicus
- Dnm3
- Saccharomyces cerevisiae
- VPS1
- Saccharomyces cerevisiae
- DNM1
In other databases
- GenAge model organism genes
- A homolog of this gene for Saccharomyces cerevisiae is present as DNM1
PIGC
Gene details
- HGNC symbol
- PIGC
- Aliases
- GPI2
- Common name
- phosphatidylinositol glycan anchor biosynthesis class C
- Description
- This gene encodes an endoplasmic reticulum associated protein that is involved in glycosylphosphatidylinositol (GPI) lipid anchor biosynthesis. The GPI lipid anchor is a glycolipid found on many blood cells and serves to anchor proteins to the cell surface. The encoded protein is one subunit of the GPI N-acetylglucosaminyl (GlcNAc) transferase that transfers GlcNAc to phosphatidylinositol (PI) on the cytoplasmic side of the endoplasmic reticulum. Two alternatively spliced transcripts that encode the same protein have been found for this gene. A pseudogene on chromosome 11 has also been characterized. [provided by RefSeq, Jul 2008]
- OMIM
- 601730
- Ensembl
- ENSG00000135845
- UniProt/Swiss-Prot
- PIGC_HUMAN
- Entrez Gene
- 5279
- UniGene
- 188456
- HapMap
- View on HapMap
Homologs in model organisms
TMCO6
Gene details
- HGNC symbol
- TMCO6
- Aliases
- PRO1580
- Common name
- transmembrane and coiled-coil domains 6
- Description
- Other longevity studies of this gene
- 2
- OMIM
- Ensembl
- ENSG00000113119
- UniProt/Swiss-Prot
- A8K0D0_HUMAN
- Entrez Gene
- 55374
- UniGene
- 534333
- HapMap
- View on HapMap