LongevityMap Gene
Gene details
- HGNC symbol
- TMCO6
- Aliases
- PRO1580
- Common name
- transmembrane and coiled-coil domains 6
- Description
- Cytogenetic Location
- 5q31.3
- UCSC Genome Browser
- View 5q31.3 on the UCSC genome browser
- OMIM
- Ensembl
- ENSG00000113119
- UniProt/Swiss-Prot
- A8K0D0_HUMAN
- Entrez Gene
- 55374
- UniGene
- 534333
- 1000 Genomes
- 1000 Genomes
Homologs in model organisms
Studies (1)
Significant/Non-significant: 0/1
- Longevity Association
- Non-significant
- Population
- American (Caucasian and African-American)
- Study Design
- The baseline levels of sCD14 (soluble form of CD14) were measured in 5888 European-American and black adults aged 65 years and older from the Cardiovascular Health Study. A genome-wide cardiovascular disease candidate gene-centric association with sCD14 was conducted separately in the European-Americans (n=2952) and blacks (n=528). Finally, the ability of sCD14 and its main genetic determinants to predict incident CVD and mortality during follow-up was assessed.
- Conclusions
- sCD14 was positively correlated with cardio-metabolic risk factors and with subclinical measures of vascular disease, and was also inversely correlated with body mass index (all P<0.001). In European Americans the minor allele at the index SNP rs5744441 was associated with lower sCD14, the C allele of index SNP rs1063412 was associated with lower sCD14. In Blacks the index SNP rs778584 was associated with higher sCD14. In the fully adjusted model, sCD14 was associated with death because of cardiovascular causes (hazard ratio=1.13, P=0.001) and death because of noncardiovascular causes (hazard ratio=1.11, P=0.001). CD14 independently predicts risk mortality in older adults. However, no SNPs were associated with risk of mortality when corrected for multiple hypothesis testing.
- Indentifier
- rs778584
- Reference