LongevityMap Gene

Gene details

HGNC symbol: CD14
Aliases
Common name: CD14 molecule
Description: The protein encoded by this gene is a surface antigen that is preferentially expressed on monocytes/macrophages. It cooperates with other proteins to mediate the innate immune response to bacterial lipopolysaccharide. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Mar 2010]
Cytogenetic Location: 5q31.3
UCSC Genome Browser: View 5q31.3 on the UCSC genome browser
OMIM: 158120
Ensembl: ENSG00000170458
UniProt/Swiss-Prot: CD14_HUMAN
Entrez Gene: 929
UniGene: 163867
1000 Genomes: 1000 Genomes

GenAge microarray genes

Significant/Non-significant: 0/2

Longevity Association: Non-significant
Population: American (Caucasian and African-American)
Study Design: The baseline levels of sCD14 (soluble form of CD14) were measured in 5888 European-American and black adults aged 65 years and older from the Cardiovascular Health Study. A genome-wide cardiovascular disease candidate gene-centric association with sCD14 was conducted separately in the European-Americans (n=2952) and blacks (n=528). Finally, the ability of sCD14 and its main genetic determinants to predict incident CVD and mortality during follow-up was assessed.
Conclusions: sCD14 was positively correlated with cardio-metabolic risk factors and with subclinical measures of vascular disease, and was also inversely correlated with body mass index (all P<0.001). In European Americans the minor allele at the index SNP rs5744441 was associated with lower sCD14, the C allele of index SNP rs1063412 was associated with lower sCD14. In Blacks the index SNP rs778584 was associated with higher sCD14. In the fully adjusted model, sCD14 was associated with death because of cardiovascular causes (hazard ratio=1.13, P=0.001) and death because of noncardiovascular causes (hazard ratio=1.11, P=0.001). CD14 independently predicts risk mortality in older adults. However, no SNPs were associated with risk of mortality when corrected for multiple hypothesis testing.
Indentifier

Longevity Association: Non-significant
Population: Italian (Southern)
Study Design: A two-stage case-control study was performed to identify the association between longevity and variation of in homeostasis regulation pathway genes. 317 SNPs in 104 genes were analyzed in 78 cases (≥90 years, median age 98 years, 42 females) and 71 controls (<90 years, median age 67 years, 32 females) in stage 1. Then, 31 candidate SNPs identified in stage 1 (π markers = 0.1) were analyzed in an independent sample composed by 288 cases (≥90 years, median age 92 years, 163 females) and 554 controls (<90 years, median age 67 years, 277 females).
Conclusions: After adjustment for multiple testing, no significant association was identified between various SNPs and longevity.
Indentifier