LongevityMap variant

Entry Details

Longevity Association: Non-significant
Population: Finnish, American, Mexican and Japanese
Study Design: The 1367 Cys/Arg polymorphism was examined during aging in 175 Finnish centenarians and 178 newborns, 169 Mexican newborns, 23 North American adults and 198 Japanese adults
Conclusions: When newborns and centenarians were compared within the Finnish population no differences were observed in the proportions of 1367 Cys/Arg across age groups. The frequency of the 1367 Arg allele, thought to be protective against myocardial infarction in a Japanese population, was approximately three times higher in the North American and Finnish adult populations.

HGNC symbol: WRN
Aliases: RECQ3; RECQL2; RECQL3
Common name: Werner syndrome RecQ like helicase
Description: This gene encodes a member of the RecQ subfamily and the DEAH (Asp-Glu-Ala-His) subfamily of DNA and RNA helicases. DNA helicases are involved in many aspects of DNA metabolism, including transcription, replication, recombination, and repair. This protein contains a nuclear localization signal in the C-terminus and shows a predominant nucleolar localization. It possesses an intrinsic 3' to 5' DNA helicase activity, and is also a 3' to 5' exonuclease. Based on interactions between this protein and Ku70/80 heterodimer in DNA end processing, this protein may be involved in the repair of double strand DNA breaks. Defects in this gene are the cause of Werner syndrome, an autosomal recessive disorder characterized by premature aging. [provided by RefSeq, Jul 2008]
Other longevity studies of this gene: 25
OMIM: 604611
Ensembl: ENSG00000165392
UniProt/Swiss-Prot: Q59F09_HUMAN
Entrez Gene: 7486
UniGene: 632050
HapMap: View on HapMap

GenAge model organism genes

GenAge human genes

CellAge

Castro et al. (1999)