GenAge entry for SGS1 (Saccharomyces cerevisiae)
Gene information (ID: 600)
- Symbol
- SGS1
- Name
- Sgs1p
- Organism
- Saccharomyces cerevisiae (AnAge)
- Known functions and activities
- Nucleolar DNA helicase of the RecQ family involved in maintenance of genome integrity
Potential relevance to longevity and/or ageing
- Observations
- Mutations cause premature ageing in mother cells including a shortened lifespan, sterility, and redistribution of the Sir3 silencing protein from telomeres to the nucleolus.
- Lifespan Effect
- Decrease
- Genetic Manipulation
- Mutations
- Longevity Category
- Necessary for fitness
- Primary reference
-
- Observations
- Replicative lifespan decreased by 30%
- % change in avg or median lifespan
- Replicative lifespan is 30% lower.
- Lifespan Effect
- Decrease
- Genetic Manipulation
- Deletion
- Longevity Category
- Pro-Longevity
- Primary reference
-
- Observations
- A shortened life span
- Lifespan Effect
- Decrease
- Genetic Manipulation
- Mutation
- Longevity Category
- Pro-Longevity
- Primary reference
-
- Observations
- To investigate the role of the RecQ helicase domain in ageing, a point mutation (SGS1 K(706)-->A) known to eliminate the DNA helicase activity of Sgs1p was constructed. This mutant allele failed to rescue the premature ageing of the sgs1Delta strain, demonstrating that Sgs1p DNA helicase activity is required for a normal lifespan
- Lifespan Effect
- Decrease
- Genetic Manipulation
- Mutation
- Longevity Category
- Pro-Longevity
- Primary reference
-
In other databases
- GenAge model organism genes
- GenAge human genes
- LongevityMap
- CellAge
- CellAge gene expression
- A homolog of this gene for Homo sapiens is present as BLM
Homologs in other organisms
- Caenorhabditis elegans
- rcq-5
- Caenorhabditis elegans
- him-6
- Caenorhabditis elegans
- K02F3.12
- Caenorhabditis elegans
- wrn-1
- Danio rerio
- recql
- Danio rerio
- recql5
- Danio rerio
- RECQL4
- Danio rerio
- wrn
- Danio rerio
- blm
- Drosophila melanogaster
- RecQ4
- Drosophila melanogaster
- RecQ5
- Drosophila melanogaster
- Blm
- Homo sapiens
- RECQL
- Homo sapiens
- RECQL4
- Homo sapiens
- WRN
- Homo sapiens
- RECQL5
- Homo sapiens
- BLM
- Mus musculus
- Recql4
- Mus musculus
- Wrn
- Mus musculus
- Recql
- Mus musculus
- Blm
- Mus musculus
- Recql5
- Rattus norvegicus
- Recql
- Rattus norvegicus
- Recql5
- Rattus norvegicus
- Wrn
- Rattus norvegicus
- Recql4
- Rattus norvegicus
- Blm
- Schizosaccharomyces pombe
- rqh1
External links
- Saccharomyces Genome Database
- Search
- Ensembl
- Search
- Entrez Gene
- View on Entrez Gene database (855228)
- Homologues
- Search HomoloGene
- UniProt
- Search
- Internet
- Search Google or Search Google Scholar