Cell Senescence Entries for WRN
- Cell Types
- Fibroblast, WRN syndrome fibroblast
- Cell Lines
- AG00780, AG03141
- Cancer Cell?
- Yes
- Method
- Knockdown
- Type of senescence
- Oncogene-induced
- Senescence Effect
- Inhibits
- Primary Reference
- Grandori et al. (2003) Werner syndrome protein limits MYC-induced cellular senescence. Genes Dev 17(13)1569-74 (PubMed)
WRN Gene Information
- HGNC symbol
- WRN
- Aliases
- RECQ3; RECQL2
- Common name
- WRN RecQ like helicase
- Entrez Id
- 7486
- Description
- This gene encodes a member of the RecQ subfamily of DNA helicase proteins. The encoded nuclear protein is important in the maintenance of genome stability and plays a role in DNA repair, replication, transcription and telomere maintenance. This protein contains a N-terminal 3' to 5' exonuclease domain, an ATP-dependent helicase domain and RQC (RecQ helicase conserved region) domain in its central region, and a C-terminal HRDC (helicase RNase D C-terminal) domain and nuclear localization signal. Defects in this gene are the cause of Werner syndrome, an autosomal recessive disorder characterized by accelerated aging and an elevated risk for certain cancers. [provided by RefSeq, Aug 2017].
WRN Ontologies
- Gene Ontology
-
Process: GO:6281; DNA repair
GO:6974; cellular response to DNA damage stimulus
GO:90305; nucleic acid phosphodiester bond hydrolysis
GO:8152; metabolic process
GO:6260; DNA replication
GO:6302; double-strand break repair
GO:6310; DNA recombination
GO:731; DNA synthesis involved in DNA repair
GO:6139; nucleobase-containing compound metabolic process
GO:6259; DNA metabolic process
GO:723; telomere maintenance
And 25 more GO terms Cellular component: GO:781; chromosome, telomeric region
GO:5634; nucleus
GO:16607; nuclear speck
GO:5694; chromosome
GO:5730; nucleolus
GO:5654; nucleoplasm
GO:5737; cytoplasm
GO:5813; centrosome
GO:5657; replication fork
GO:43005; neuron projection
Show all GO termsFunction: GO:5515; protein binding
GO:3676; nucleic acid binding
GO:46872; metal ion binding
GO:166; nucleotide binding
GO:5524; ATP binding
GO:3677; DNA binding
GO:16787; hydrolase activity
GO:42803; protein homodimerization activity
GO:4518; nuclease activity
GO:3824; catalytic activity
GO:4386; helicase activity
And 21 more GO terms
Homologs of WRN in Model Organisms
- Caenorhabditis elegans
- wrn-1
- Danio rerio
- wrn
- Mus musculus
- Wrn
- Rattus norvegicus
- Wrn
- Saccharomyces cerevisiae
- SGS1
In other databases
- GenAge model organism genes
- A homolog of this gene for Saccharomyces cerevisiae is present as SGS1
- GenAge human genes
- This gene is present as WRN
- LongevityMap
- This gene is present as WRN
External links
- OMIM
- 604611
- Ensembl
- ENSG00000165392
- Entrez Gene
- 7486
- UniGene
- 632050
- 1000 Genomes
- 1000 Genomes
- HPRD
- GenAtlas
- WRN
- GeneCards
- WRN