LongevityMap variant

Entry Details

Longevity Association: Significant
Population: Italian
Study Design: A Leucine (L allele) to Methionine (M allele) substitution at codon 55, and a Glutamine (A allele) to Arginine (B allele) substitution at codon 192 were examined in 579 people aged 20 to 65 years old, and in 308 centenarians
Conclusions: Significant differences between young people and centenarians were observed. The percentage of carriers of the B allele at codon 192 is higher in centenarians than in controls (0.539 vs 0.447), though this was due to an increase of people carrying M alleles at codon 55.

HGNC symbol: PON1
Aliases: ESA; PON; MVCD5
Common name: paraoxonase 1
Description: The enzyme encoded by this gene is an arylesterase that mainly hydrolyzes paroxon to produce p-nitrophenol. Paroxon is an organophosphorus anticholinesterase compound that is produced in vivo by oxidation of the insecticide parathion. Polymorphisms in this gene are a risk factor in coronary artery disease. The gene is found in a cluster of three related paraoxonase genes at 7q21.3. [provided by RefSeq, Oct 2008]
Other longevity studies of this gene: 31
OMIM: 168820
Ensembl: ENSG00000005421
UniProt/Swiss-Prot: PON1_HUMAN
Entrez Gene: 5444
UniGene: 370995
HapMap: View on HapMap

GenAge human genes

CellAge

Bonafè et al. (2002)