LongevityMap variant
Entry Details
- Longevity Association
- Non-significant
- Population
- Japanese
- Study Design
- 2 promoter and 1 intron polymorphisms were examined in 122 semisupercentenarians (older than 105, 107 female, 15 male, mean age 106.8 years) and 122 healthy younger controls (105 female, 17 male, mean age 33.33)
- Conclusions
- No significant differences relative to longevity were found
- Identifier
- PIK3CB
- In Other Studies (IDs)
- 121
- Cytogenetic Location
- 3q22.3
- UCSC Genome Browser
- View 3q22.3 on the UCSC genome browser
Gene details
- HGNC symbol
- PIK3CB
- Aliases
- PI3K; PIK3C1; P110BETA; PI3KBETA
- Common name
- phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta
- Description
- This gene encodes an isoform of the catalytic subunit of phosphoinositide 3-kinase (PI3K). These kinases are important in signaling pathways involving receptors on the outer membrane of eukaryotic cells and are named for their catalytic subunit. The encoded protein is the catalytic subunit for PI3Kbeta (PI3KB). PI3KB has been shown to be part of the activation pathway in neutrophils which have bound immune complexes at sites of injury or infection. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2011]
- Other longevity studies of this gene
- 1
- OMIM
- 602925
- Ensembl
- ENSG00000051382
- UniProt/Swiss-Prot
- B4DER4_HUMAN
- Entrez Gene
- 5291
- UniGene
- 239818
- HapMap
- View on HapMap
Homologs in model organisms
- Danio rerio
- pik3cb
- Drosophila melanogaster
- Pi3K92E
- Mus musculus
- Pik3cb
- Rattus norvegicus
- Pik3cb
- Rattus norvegicus
- LOC100910021
- Saccharomyces cerevisiae
- VPS34