Drosophila melanogasterGenAge entry for Pi3K92E (Drosophila melanogaster)

Gene information (ID: 874)

Symbol
Pi3K92E
Aliases
anon-92Ed; CG4141; Dmel\CG4141; Dmp110; dp110; dP110; Dp
Name
CG4141 gene product from transcript CG4141-RA
Organism
Drosophila melanogaster (AnAge)

Potential relevance to longevity and/or ageing

Observations
Overexpression of a dominant-negative PI3Kinase (DP110) resulted in mutants that have impaired regeneration of the intestinal epithelium and are short lived.
% change in avg or median lifespan
Average male lifespan is 2.8% lower; Average female lifespan is 5.0% lower.
Lifespan Effect
Decrease
Genetic Manipulation
Knock-down
Longevity Category
Pro-Longevity
Primary reference

    In other databases

    GenAge model organism genes
    • A homolog of this gene for Saccharomyces cerevisiae is present as VPS34
    GenAge human genes
    • A homolog of this gene for Homo sapiens is present as PIK3CA
    • A homolog of this gene for Homo sapiens is present as PIK3CB
    LongevityMap
    • A homolog of this gene for Homo sapiens is present as PIK3CA
    • A homolog of this gene for Homo sapiens is present as PIK3CB
    CellAge
    • A homolog of this gene for Homo sapiens is present as PIK3CA

    Homologs in other organisms

    Danio rerio
    zgc:158659
    Danio rerio
    pik3cb
    Danio rerio
    pik3cd
    Danio rerio
    pik3ca
    Homo sapiens
    PIK3CD
    Homo sapiens
    PIK3CB
    Homo sapiens
    PIK3CA
    Mus musculus
    Pik3cb
    Mus musculus
    Pik3ca
    Mus musculus
    Pik3cd
    Rattus norvegicus
    Pik3cd
    Rattus norvegicus
    Pik3ca
    Rattus norvegicus
    Pik3cb
    Rattus norvegicus
    AABR07037536.1
    Rattus norvegicus
    LOC100910021
    Saccharomyces cerevisiae
    VPS34

    External links

    FlyBase
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    Ensembl
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    Entrez Gene
    View on Entrez Gene database (42446)
    Homologues
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    UniProt
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    Internet
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