GenAge entry for PIK3CB (Homo sapiens)
Gene name (HAGRID: 36)
- HGNC symbol
- PIK3CB
- Aliases
- PIK3C1
- Common name
- phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta
Potential relevance to the human ageing process
- Main reason for selection
- Entry selected based on evidence directly linking the gene product to ageing in a non-mammalian animal model
- Description
PIK3CB is involved in the signal transduction of insulin (INS) and insulin-like pathways including the activation of the MAPK pathway [154]. A homologue of PIK3CB, age-1, has been related to ageing in roundworms [1518]. Genotype combinations in the human PIK3CB and IGF1R genes have been related to plasma IGF1 levels and longevity [141], though the elucidation of PIK3CB's role in ageing will require more detailed studies.
Cytogenetic information
- Cytogenetic band
- 3q22.3
- Location
- 138,652,698 bp to 138,759,359 bp
- Orientation
- Minus strand
Protein information
- Gene Ontology
-
Process: GO:0000187; activation of MAPK activity
GO:0001935; endothelial cell proliferation
GO:0001952; regulation of cell-matrix adhesion
GO:0006661; phosphatidylinositol biosynthetic process
GO:0006874; cellular calcium ion homeostasis
GO:0006914; autophagy
GO:0006935; chemotaxis
GO:0007156; homophilic cell adhesion via plasma membrane adhesion molecules
GO:0007165; signal transduction
GO:0007169; transmembrane receptor protein tyrosine kinase signaling pathway
GO:0007186; G-protein coupled receptor signaling pathway
And 20 more GO terms Cellular component: GO:0005634; nucleus
GO:0005730; nucleolus
GO:0005829; cytosol
GO:0005886; plasma membrane
GO:0005942; phosphatidylinositol 3-kinase complex
GO:0045171; intercellular bridge
Function: GO:0005515; protein binding
GO:0005524; ATP binding
GO:0016301; kinase activity
GO:0016303; 1-phosphatidylinositol-3-kinase activity
GO:0035004; phosphatidylinositol 3-kinase activity
GO:0035005; 1-phosphatidylinositol-4-phosphate 3-kinase activity
GO:0043560; insulin receptor substrate binding
GO:0046934; phosphatidylinositol-4,5-bisphosphate 3-kinase activity
Protein interactions and network
- Protein-protein interacting partners in GenAge
- IRS1, AKT1, EGFR, PRKCD, GRB2, PIK3R1
- STRING interaction network
Retrieve sequences for PIK3CB
Homologs in model organisms
- Danio rerio
- pik3cb
- Drosophila melanogaster
- Pi3K92E
- Mus musculus
- Pik3cb
- Rattus norvegicus
- Pik3cb
- Rattus norvegicus
- LOC100910021
- Saccharomyces cerevisiae
- VPS34
In other databases
- GenAge model organism genes
- LongevityMap
- This gene is present as PIK3CB
Selected references
External links
- EPD
- ORF Accession
- NM_006219
- CDS Accession
- NP_006210
- OMIM
- 602925
- HPRD
- 04234
- Ensembl
- PIK3CB
- UniProt/Swiss-Prot
- PK3CB_HUMAN
- GeneCards
- PIK3CB
- Entrez Gene
- 5291
- GenAtlas
- PIK3CB
- Internet
- Search Google