GenAge entry for LMNB1 (Homo sapiens)

Gene name (HAGRID: 181)

HGNC symbol: LMNB1
Aliases
Common name: lamin B1

Potential relevance to the human ageing process

Main reason for selection: Entry selected based on evidence linking the gene product to a pathway or mechanism linked to ageing
Description: LMNAB1 is, like LMNA, part of the nuclear lamina [1001]. LMNB1-null mice die shortly after birth [1724]. If the nuclear lamina is a player in human ageing, as some results from LMNA suggest [1307], then it is possible that LMNB1 also plays some role in human ageing.

Cytogenetic information

Cytogenetic band: 5q23.2
Location: 126,776,623 bp to 126,837,020 bp
Orientation: Plus strand

Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology

Process:

Cellular component:

GO:0005635; nuclear envelope
GO:0005637; nuclear inner membrane
GO:0005638; lamin filament
GO:0005654; nucleoplasm
GO:0016020; membrane
GO:0016363; nuclear matrix
GO:0031965; nuclear membrane

Function:

GO:0005198; structural molecule activity
GO:0005515; protein binding
GO:0043274; phospholipase binding

Show all GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge: LMNA, EGF, RPA1, PRKCA, EMD, HSPA8, CDK1, CTNNB1, SPRTN
STRING interaction network

Retrieve sequences for LMNB1

ORF: ORF
CDS: CDS

Homologs in model organisms

Caenorhabditis elegans: lmn-1
Danio rerio: lmnb1
Drosophila melanogaster: LamC
Drosophila melanogaster: Lam
Mus musculus: Lmnb1
Rattus norvegicus: Lmnb1

In other databases

GenAge model organism genes

A homolog of this gene for Caenorhabditis elegans is present as lmn-1

CellAge

This gene is present as LMNB1

CellAge gene expression

This gene is present as LMNB1