- Symbol
- daf-18
- Name
- Abnormal DAuer Formation
- Organism
- Caenorhabditis elegans (AnAge)
- Known functions and activities
- Lipid phosphatase
- Observations
- Knockdown of daf-18 decreased lifespan.
- Lifespan Effect
- Decrease
- Genetic Manipulation
- RNA interference
- Longevity Category
- Pro-Longevity
- Primary reference
-
- Observations
- The increased lifespan of daf-2 mutants is partially suppressed in a daf- 2; daf-18 double mutant.
- Lifespan Effect
- Not Recorded
- Genetic Manipulation
- Mutations
- Longevity Category
- Pro-Longevity
- Primary reference
-
- Observations
- Required for complete dauer formation. Overexpression increases adult lifespan in individual tissues.
- Lifespan Effect
- Increase
- Genetic Manipulation
- Overexpression
- Longevity Category
- Pro-Longevity
- Primary reference
-
- Observations
- Overexpression resulted in a 30% mean lifespan extension.
- % change in avg or median lifespan
- Average lifespan is 30% higher.
- Lifespan Effect
- Increase
- Genetic Manipulation
- Overexpression
- Longevity Category
- Pro-Longevity
- Primary reference
-
- GenAge model organism genes
- A homolog of this gene for Drosophila melanogaster is present as Pten
- A homolog of this gene for Mus musculus is present as Pten
- GenAge human genes
- A homolog of this gene for Homo sapiens is present as PTEN
- CellAge
- A homolog of this gene for Homo sapiens is present as PTEN
- Danio rerio
- ptena
- Danio rerio
- ptenb
- Drosophila melanogaster
- Pten
- Homo sapiens
- PTEN
- Mus musculus
- Pten
- Rattus norvegicus
- Pten
- WormBase
- Search
- Ensembl
- Search
- Entrez Gene
- View on Entrez Gene database (176869)
- Homologues
- Search HomoloGene
- UniProt
- Search
- Internet
- Search Google or Search Google Scholar
GenAge entry for daf-18 (Caenorhabditis elegans)