LongevityMap variant group
Entry Details
- Longevity Association
- Significant
- Population
- Danish
- Study Design
- 38 genes (311 SNPs) belonging to pro-antioxidant pathways were investigated for the association with physical and cognitive performances in a Cohort of 1089 Danish nonagenarians. For each gene analyzed in the pro-antioxidant pathway, the influence on longitudinal survival was tested.
- Conclusions
- NDUFS1, TXNRD1, SOD2 and UCP3 were found significantly associated with lifespan in the female cohort. This result is consistent with their associations with physical functioning and suggests that the variability of genes in the pro-antioxidant pathway can influence survival through an effect on physical performances, at least in the analyzed cohort.
Variants (15)
1.
- Identifier
- rs10861169
- Cytogenetic Location
- 12q23.3
- UCSC Genome Browser
- View 12q23.3 on the UCSC genome browser
2.
- Identifier
- rs10861171
- Cytogenetic Location
- 12q23.3
- UCSC Genome Browser
- View 12q23.3 on the UCSC genome browser
3.
- Identifier
- rs10861197
- Cytogenetic Location
- 12q23.3
- UCSC Genome Browser
- View 12q23.3 on the UCSC genome browser
4.
- Identifier
- rs10861203
- Cytogenetic Location
- 12q23.3
- UCSC Genome Browser
- View 12q23.3 on the UCSC genome browser
5.
- Identifier
- rs17202060
- Cytogenetic Location
- 12q23.3
- UCSC Genome Browser
- View 12q23.3 on the UCSC genome browser
6.
- Identifier
- rs4445711
- Cytogenetic Location
- 12q23.3
- UCSC Genome Browser
- View 12q23.3 on the UCSC genome browser
7.
- Identifier
- rs4964728
- Cytogenetic Location
- 12q23.3
- UCSC Genome Browser
- View 12q23.3 on the UCSC genome browser
8.
- Identifier
- rs4964735
- Cytogenetic Location
- 12q23.3
- UCSC Genome Browser
- View 12q23.3 on the UCSC genome browser
9.
- Identifier
- rs4964778
- Cytogenetic Location
- 12q23.3
- UCSC Genome Browser
- View 12q23.3 on the UCSC genome browser
10.
- Identifier
- rs7301631
- Cytogenetic Location
- 12q23.3
- UCSC Genome Browser
- View 12q23.3 on the UCSC genome browser
11.
- Identifier
- rs7310505
- Cytogenetic Location
- 12q23.3
- UCSC Genome Browser
- View 12q23.3 on the UCSC genome browser
12.
- Identifier
- rs7310815
- Cytogenetic Location
- 12q23.3
- UCSC Genome Browser
- View 12q23.3 on the UCSC genome browser
13.
- Identifier
- rs7962759
- Cytogenetic Location
- 12q23.3
- UCSC Genome Browser
- View 12q23.3 on the UCSC genome browser
14.
- Identifier
- rs10047589
- In Other Studies (IDs)
- 269
- Cytogenetic Location
- 12q23.3
- UCSC Genome Browser
- View 12q23.3 on the UCSC genome browser
15.
- Identifier
- rs10778318
- Cytogenetic Location
- 12q23.3
- UCSC Genome Browser
- View 12q23.3 on the UCSC genome browser
Gene details
- HGNC symbol
- TXNRD1
- Aliases
- TR; TR1; TXNR; TRXR1; GRIM-12
- Common name
- thioredoxin reductase 1
- Description
- This gene encodes a member of the family of pyridine nucleotide oxidoreductases. This protein reduces thioredoxins as well as other substrates, and plays a role in selenium metabolism and protection against oxidative stress. The functional enzyme is thought to be a homodimer which uses FAD as a cofactor. Each subunit contains a selenocysteine (Sec) residue which is required for catalytic activity. The selenocysteine is encoded by the UGA codon that normally signals translation termination. The 3' UTR of selenocysteine-containing genes have a common stem-loop structure, the sec insertion sequence (SECIS), that is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. Alternative splicing results in several transcript variants encoding the same or different isoforms. [provided by RefSeq, Jul 2008]
- Other longevity studies of this gene
- 15
- OMIM
- 601112
- Ensembl
- ENSG00000198431
- UniProt/Swiss-Prot
- B7Z2S5_HUMAN
- Entrez Gene
- 7296
- UniGene
- 654922
- HapMap
- View on HapMap