LongevityMap variant
Entry Details
- Longevity Association
- Significant
- Population
- Danish
- Study Design
- Alleles in candidate pathways (GH/IGF1 signaling, DNA damage signaling and repair and pro/antioxidants) were investigated for association with longevity in 1089 oldest-old (age 92-93) and 736 middle-aged Danes
- Conclusions
- Six SNPs (in TNXRD1, XDH, GHRL, MLH1, H2AFX, XRCC5) were associated with mortality in late life after correction for multiple hypothesis testing. No replications were observed in German and Dutch populations.
- Identifier
- rs10047589
- In Other Studies (IDs)
- 2340
- Cytogenetic Location
- 12q23.3
- UCSC Genome Browser
- View 12q23.3 on the UCSC genome browser
Gene details
- HGNC symbol
- TXNRD1
- Aliases
- TR; TR1; TXNR; TRXR1; GRIM-12
- Common name
- thioredoxin reductase 1
- Description
- This gene encodes a member of the family of pyridine nucleotide oxidoreductases. This protein reduces thioredoxins as well as other substrates, and plays a role in selenium metabolism and protection against oxidative stress. The functional enzyme is thought to be a homodimer which uses FAD as a cofactor. Each subunit contains a selenocysteine (Sec) residue which is required for catalytic activity. The selenocysteine is encoded by the UGA codon that normally signals translation termination. The 3' UTR of selenocysteine-containing genes have a common stem-loop structure, the sec insertion sequence (SECIS), that is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. Alternative splicing results in several transcript variants encoding the same or different isoforms. [provided by RefSeq, Jul 2008]
- Other longevity studies of this gene
- 15
- OMIM
- 601112
- Ensembl
- ENSG00000198431
- UniProt/Swiss-Prot
- B7Z2S5_HUMAN
- Entrez Gene
- 7296
- UniGene
- 654922
- HapMap
- View on HapMap