LongevityMap variant group

Entry Details

Longevity Association: Non-significant
Population: American of Japanese origin
Study Design: 85 multiethnic (Caucasian, Filipino, Japanese, Chinese, and mixed ethnicity; aged 10- 78 y) sequences were chosen to determine allele frequency. Then 282 Americans of Japanese ancestry were examined for the allele frequency. Furthermore, 675 Hawaii Lifespan Study case (>95 y, average 97.9 y)-control(< 81 y, average 78.5 y) study participants were examined for the allele frequency.
Conclusions: All 38 of the previously reported coding SNPs in FOXO3 are either invalid or too rare to be useful for phenotype–genotype association and other genetic mapping studies. These are likely not involved in longevity. A novel identified SNP (rs138174682) is prevalent in multiple ethnic groups but too rare for longevity analysis in Hawaii Lifespan Study.

Variants (39)

Identifier: rs150535671
Cytogenetic Location: 6q21
UCSC Genome Browser: View 6q21 on the UCSC genome browser

Identifier: rs147028825
Cytogenetic Location: 6q21
UCSC Genome Browser: View 6q21 on the UCSC genome browser

Identifier: rs148296241
Cytogenetic Location: 6q21
UCSC Genome Browser: View 6q21 on the UCSC genome browser

Identifier: rs148405845
Cytogenetic Location: 6q21
UCSC Genome Browser: View 6q21 on the UCSC genome browser

Identifier: rs149158541
Cytogenetic Location: 6q21
UCSC Genome Browser: View 6q21 on the UCSC genome browser

Identifier: rs149189425
Cytogenetic Location: 6q21
UCSC Genome Browser: View 6q21 on the UCSC genome browser

Identifier: rs149503832
Cytogenetic Location: 6q21
UCSC Genome Browser: View 6q21 on the UCSC genome browser

Identifier: rs149906214
Cytogenetic Location: 6q21
UCSC Genome Browser: View 6q21 on the UCSC genome browser

Identifier: rs150216371
Cytogenetic Location: 6q21
UCSC Genome Browser: View 6q21 on the UCSC genome browser

10.

Identifier: rs150320900
Cytogenetic Location: 6q21
UCSC Genome Browser: View 6q21 on the UCSC genome browser

11.

Identifier: rs147010831
Cytogenetic Location: 6q21
UCSC Genome Browser: View 6q21 on the UCSC genome browser

12.

Identifier: rs34079373
Cytogenetic Location: 6q21
UCSC Genome Browser: View 6q21 on the UCSC genome browser

13.

Identifier: rs34133353
Cytogenetic Location: 6q21
UCSC Genome Browser: View 6q21 on the UCSC genome browser

14.

Identifier: rs34223850
Cytogenetic Location: 6q21
UCSC Genome Browser: View 6q21 on the UCSC genome browser

15.

Identifier: rs34488332
Cytogenetic Location: 6q21
UCSC Genome Browser: View 6q21 on the UCSC genome browser

16.

Identifier: rs34600091
Cytogenetic Location: 6q21
UCSC Genome Browser: View 6q21 on the UCSC genome browser

17.

Identifier: rs34754045
Cytogenetic Location: 6q21
UCSC Genome Browser: View 6q21 on the UCSC genome browser

18.

Identifier: rs61756661
Cytogenetic Location: 6q21
UCSC Genome Browser: View 6q21 on the UCSC genome browser

19.

Identifier: rs61758963
Cytogenetic Location: 6q21
UCSC Genome Browser: View 6q21 on the UCSC genome browser

20.

Identifier: rs79884776
Cytogenetic Location: 6q21
UCSC Genome Browser: View 6q21 on the UCSC genome browser

21.

Identifier: rs141876866
Cytogenetic Location: 6q21
UCSC Genome Browser: View 6q21 on the UCSC genome browser

22.

Identifier: rs112124249
Cytogenetic Location: 6q21
UCSC Genome Browser: View 6q21 on the UCSC genome browser

23.

Identifier: rs11551770
Cytogenetic Location: 6q21
UCSC Genome Browser: View 6q21 on the UCSC genome browser

24.

Identifier: rs11757217
Cytogenetic Location: 6q21
UCSC Genome Browser: View 6q21 on the UCSC genome browser

25.

Identifier: rs13204476
Cytogenetic Location: 6q21
UCSC Genome Browser: View 6q21 on the UCSC genome browser

26.

Identifier: rs138174682
Cytogenetic Location: 6q21
UCSC Genome Browser: View 6q21 on the UCSC genome browser

27.

Identifier: rs138297794
Cytogenetic Location: 6q21
UCSC Genome Browser: View 6q21 on the UCSC genome browser

28.

Identifier: rs138742093
Cytogenetic Location: 6q21
UCSC Genome Browser: View 6q21 on the UCSC genome browser

29.

Identifier: rs139172563
Cytogenetic Location: 6q21
UCSC Genome Browser: View 6q21 on the UCSC genome browser

30.

Identifier: rs140968061
Cytogenetic Location: 6q21
UCSC Genome Browser: View 6q21 on the UCSC genome browser

31.

Identifier: rs111556510
Cytogenetic Location: 6q21
UCSC Genome Browser: View 6q21 on the UCSC genome browser

32.

Identifier: rs141893794
Cytogenetic Location: 6q21
UCSC Genome Browser: View 6q21 on the UCSC genome browser

33.

Identifier: rs142429317
Cytogenetic Location: 6q21
UCSC Genome Browser: View 6q21 on the UCSC genome browser

34.

Identifier: rs142533192
Cytogenetic Location: 6q21
UCSC Genome Browser: View 6q21 on the UCSC genome browser

35.

Identifier: rs145259784
Cytogenetic Location: 6q21
UCSC Genome Browser: View 6q21 on the UCSC genome browser

36.

Identifier: rs145756480
Cytogenetic Location: 6q21
UCSC Genome Browser: View 6q21 on the UCSC genome browser

37.

Identifier: rs146009555
Cytogenetic Location: 6q21
UCSC Genome Browser: View 6q21 on the UCSC genome browser

38.

Identifier: rs146169955
Cytogenetic Location: 6q21
UCSC Genome Browser: View 6q21 on the UCSC genome browser

39.

Identifier: rs146186567
Cytogenetic Location: 6q21
UCSC Genome Browser: View 6q21 on the UCSC genome browser

Gene details

HGNC symbol: FOXO3
Aliases: FOXO2; AF6q21; FKHRL1; FOXO3A; FKHRL1P2
Common name: forkhead box O3
Description: This gene belongs to the forkhead family of transcription factors which are characterized by a distinct forkhead domain. This gene likely functions as a trigger for apoptosis through expression of genes necessary for cell death. Translocation of this gene with the MLL gene is associated with secondary acute leukemia. Alternatively spliced transcript variants encoding the same protein have been observed. [provided by RefSeq, Jul 2008]
Other longevity studies of this gene: 101
OMIM: 602681
Ensembl: ENSG00000118689
UniProt/Swiss-Prot: FOXO3_HUMAN
Entrez Gene: 2309
UniGene: 220950
HapMap: View on HapMap

Homologs in model organisms

Caenorhabditis elegans: daf-16
Danio rerio: foxo3a
Danio rerio: foxo3b
Drosophila melanogaster: foxo
Mus musculus: Foxo3
Rattus norvegicus: Foxo3
Saccharomyces cerevisiae: HCM1

In other databases

GenAge model organism genes

A homolog of this gene for Caenorhabditis elegans is present as daf-16
A homolog of this gene for Drosophila melanogaster is present as foxo
A homolog of this gene for Saccharomyces cerevisiae is present as HCM1

GenAge human genes

This gene is present as FOXO3

GenDR gene manipulations

A homolog of this gene for Drosophila melanogaster is present as foxo
A homolog of this gene for Mus musculus is present as Foxo3
A homolog of this gene for Caenorhabditis elegans is present as daf-16

CellAge

This gene is present as FOXO3

References

Donlon et al. (2012)