LongevityMap variant

Entry Details

Longevity Association: Significant
Population: American (Caucasian)
Study Design: Surviving participants of a 30-year-old population-based health survey (N = 310; age range, 90–109 years; the 90+ Study) were genotyped/resequenced at the DRD4 gene and compared with a European ancestry-matched younger population (N = 2902; age range, 7–45 years)
Conclusions: Oldest-old population carrying the DRD4 7R allele was higher relative to the younger sample (p = 3.5 × 10−9). And DRD4 7R genotype was strongly correlated with increased levels of physical activity.

HGNC symbol: DRD4
Aliases: D4DR
Common name: dopamine receptor D4
Description: This gene encodes the D4 subtype of the dopamine receptor. The D4 subtype is a G-protein coupled receptor which inhibits adenylyl cyclase. It is a target for drugs which treat schizophrenia and Parkinson disease. Mutations in this gene have been associated with various behavioral phenotypes, including autonomic nervous system dysfunction, attention deficit/hyperactivity disorder, and the personality trait of novelty seeking. This gene contains a polymorphic number (2-10 copies) of tandem 48 nt repeats; the sequence shown contains four repeats. [provided by RefSeq, Jul 2008]
Other longevity studies of this gene: 3
OMIM: 126452
Ensembl: ENSG00000069696
UniProt/Swiss-Prot: A0A0G2JM26_HUMAN
Entrez Gene: 1815
UniGene: 99922
HapMap: View on HapMap

Grady et al. (2013)