LongevityMap Gene
Gene details
- HGNC symbol
- DRD4
- Aliases
- D4DR
- Common name
- dopamine receptor D4
- Description
- This gene encodes the D4 subtype of the dopamine receptor. The D4 subtype is a G-protein coupled receptor which inhibits adenylyl cyclase. It is a target for drugs which treat schizophrenia and Parkinson disease. Mutations in this gene have been associated with various behavioral phenotypes, including autonomic nervous system dysfunction, attention deficit/hyperactivity disorder, and the personality trait of novelty seeking. This gene contains a polymorphic number (2-10 copies) of tandem 48 nt repeats; the sequence shown contains four repeats. [provided by RefSeq, Jul 2008]
- Cytogenetic Location
- 11p15.5
- UCSC Genome Browser
- View 11p15.5 on the UCSC genome browser
- OMIM
- 126452
- Ensembl
- ENSG00000069696
- UniProt/Swiss-Prot
- A0A0G2JM26_HUMAN
- Entrez Gene
- 1815
- UniGene
- 99922
- 1000 Genomes
- 1000 Genomes
Homologs in model organisms
- Danio rerio
- drd4a
- Danio rerio
- drd4b
- Drosophila melanogaster
- TyrR
- Drosophila melanogaster
- TyrRII
- Mus musculus
- Drd4
- Rattus norvegicus
- Drd4
Studies (2)
Significant/Non-significant: 1/1
Study 1
- Longevity Association
- Significant
- Population
- American (Caucasian)
- Study Design
- Surviving participants of a 30-year-old population-based health survey (N = 310; age range, 90–109 years; the 90+ Study) were genotyped/resequenced at the DRD4 gene and compared with a European ancestry-matched younger population (N = 2902; age range, 7–45 years)
- Conclusions
- Oldest-old population carrying the DRD4 7R allele was higher relative to the younger sample (p = 3.5 × 10−9). And DRD4 7R genotype was strongly correlated with increased levels of physical activity.
- Indentifier
- DRD4 7R
- Reference
Study 2
- Longevity Association
- Non-significant
- Population
- Italian (Southern)
- Study Design
- A two-stage case-control study was performed to identify the association between longevity and variation of in homeostasis regulation pathway genes. 317 SNPs in 104 genes were analyzed in 78 cases (≥90 years, median age 98 years, 42 females) and 71 controls (<90 years, median age 67 years, 32 females) in stage 1. Then, 31 candidate SNPs identified in stage 1 (π markers = 0.1) were analyzed in an independent sample composed by 288 cases (≥90 years, median age 92 years, 163 females) and 554 controls (<90 years, median age 67 years, 277 females).
- Conclusions
- After adjustment for multiple testing, no significant association was identified between various SNPs and longevity.
- Indentifier
- rs936461
- Reference