LongevityMap variant

Entry Details

Longevity Association: Significant
Population: Danish
Study Design: The -110A/C polymorphism was examined in a cohort of aged Danish twins (individuals aged between 70 and 91 years, categorized according to the presence or absence of various diseases)
Conclusions: An association was found between low self-rated health and heterozygosity (AC genotype)

HGNC symbol: HSPA1A
Aliases: HSP72; HSPA1; HSP70I; HSP70-1; HSP70.1; HSP70-1A; HEL-S-103
Common name: heat shock protein family A (Hsp70) member 1A
Description: This intronless gene encodes a 70kDa heat shock protein which is a member of the heat shock protein 70 family. In conjuction with other heat shock proteins, this protein stabilizes existing proteins against aggregation and mediates the folding of newly translated proteins in the cytosol and in organelles. It is also involved in the ubiquitin-proteasome pathway through interaction with the AU-rich element RNA-binding protein 1. The gene is located in the major histocompatibility complex class III region, in a cluster with two closely related genes which encode similar proteins. [provided by RefSeq, Jul 2008]
Other longevity studies of this gene: 7
OMIM: 140550
Ensembl: ENSG00000204389
UniProt/Swiss-Prot: A8K5I0_HUMAN
Entrez Gene: 3303
UniGene: 274402
HapMap: View on HapMap

GenAge human genes

CellAge

Singh et al. (2004)