LongevityMap variant

Entry Details

Longevity Association: Significant
Population: Italian (Southern)
Study Design: (A/C)-110 polymorphism was examined in 591 subjects (263 males and 328 females; age range 18-109 years; 36 male and 84 female centenarians)
Conclusions: A significant age-related decrease of the frequency of allele (A)-110 was observed in females, while no difference was observed in the males

HGNC symbol: HSPA1A
Aliases: HSP72; HSPA1; HSP70I; HSP70-1; HSP70.1; HSP70-1A; HEL-S-103
Common name: heat shock protein family A (Hsp70) member 1A
Description: This intronless gene encodes a 70kDa heat shock protein which is a member of the heat shock protein 70 family. In conjuction with other heat shock proteins, this protein stabilizes existing proteins against aggregation and mediates the folding of newly translated proteins in the cytosol and in organelles. It is also involved in the ubiquitin-proteasome pathway through interaction with the AU-rich element RNA-binding protein 1. The gene is located in the major histocompatibility complex class III region, in a cluster with two closely related genes which encode similar proteins. [provided by RefSeq, Jul 2008]
Other longevity studies of this gene: 7
OMIM: 140550
Ensembl: ENSG00000204389
UniProt/Swiss-Prot: A8K5I0_HUMAN
Entrez Gene: 3303
UniGene: 274402
HapMap: View on HapMap

GenAge human genes

CellAge

Altomare et al. (2003)