LongevityMap variant
- Longevity Association
- Non-significant
- Population
- Korean
- Study Design
- Common polymorphism was examined in 103 centenarians (13 men and 90 women, mean age 102.4 +/- 2.6 years) and in 6435 adults (5008 men and 1427 women) of mean age 50.7 +/- 7.9 years
- Conclusions
- The frequencies of genotypes and alleles of the centenarians were not significantly different from those of the control groups. The frequency of the E4 allele, however, was significantly higher in centenarians with dementia than in centenarians without definitive dementia.
- HGNC symbol
- APOE
- Aliases
- AD2; LPG; APO-E; ApoE4; LDLCQ5
- Common name
- apolipoprotein E
- Description
- The protein encoded by this gene is a major apoprotein of the chylomicron. It binds to a specific liver and peripheral cell receptor, and is essential for the normal catabolism of triglyceride-rich lipoprotein constituents. This gene maps to chromosome 19 in a cluster with the related apolipoprotein C1 and C2 genes. Mutations in this gene result in familial dysbetalipoproteinemia, or type III hyperlipoproteinemia (HLP III), in which increased plasma cholesterol and triglycerides are the consequence of impaired clearance of chylomicron and VLDL remnants. [provided by RefSeq, Jun 2016]
- Other longevity studies of this gene
- 30
- OMIM
- 107741
- Ensembl
- ENSG00000130203
- UniProt/Swiss-Prot
- A0A0S2Z3D5_HUMAN
- Entrez Gene
- 348
- UniGene
- 654439
- HapMap
- View on HapMap
Homologs in model organisms
- Danio rerio
- apoea
- Danio rerio
- apoeb
- Mus musculus
- Apoe
- Rattus norvegicus
- Apoe
- GenAge model organism genes
- A homolog of this gene for Mus musculus is present as Apoe
- GenAge human genes
- This gene is present as APOE
- GenAge microarray genes
- This gene is present as APOE
Choi et al. (2003)
Other variants which are also part of this study