LongevityMap variant
Entry Details
- Longevity Association
- Significant
- Population
- Chinese (Uighur in Xinjiang)
- Study Design
- Common polymorphism was examined in centenarians (n=42), 90-year-old people (n=102), 65-70-year-old people (n=70) and controls(n=53).
- Conclusions
- The frequencies of genotype E3/4 and E4, E3 alleles in the centenarian group were significantly lower than those in controls, whereas the frequencies of genotype E2/3 and E2 allele in the centenarian group were significantly higher than those in controls.
Gene details
- HGNC symbol
- APOE
- Aliases
- AD2; LPG; APO-E; ApoE4; LDLCQ5
- Common name
- apolipoprotein E
- Description
- The protein encoded by this gene is a major apoprotein of the chylomicron. It binds to a specific liver and peripheral cell receptor, and is essential for the normal catabolism of triglyceride-rich lipoprotein constituents. This gene maps to chromosome 19 in a cluster with the related apolipoprotein C1 and C2 genes. Mutations in this gene result in familial dysbetalipoproteinemia, or type III hyperlipoproteinemia (HLP III), in which increased plasma cholesterol and triglycerides are the consequence of impaired clearance of chylomicron and VLDL remnants. [provided by RefSeq, Jun 2016]
- Other longevity studies of this gene
- 30
- OMIM
- 107741
- Ensembl
- ENSG00000130203
- UniProt/Swiss-Prot
- A0A0S2Z3D5_HUMAN
- Entrez Gene
- 348
- UniGene
- 654439
- HapMap
- View on HapMap