LongevityMap variant
Entry Details
- Longevity Association
- Significant
- Population
- American (Georgia and Louisiana populations from African and European origin)
- Study Design
- Haplotype analysis was performed in three candidate genes, and the haplotype combinations were tested for association with exceptional longevity in the Georgia Centenarian Study (n=650) and Louisiana Healthy Aging Study (n=869)
- Conclusions
- An HRAS1 haplotype enhanced the effect of an APOE haplotype on exceptional survival, and a LASS1 haplotype further augmented its magnitude. These results were replicated in a second population.
- Identifier
- CERS1
- In Other Studies (IDs)
- 3470
- Cytogenetic Location
- 19p13.11
- UCSC Genome Browser
- View 19p13.11 on the UCSC genome browser
Gene details
- HGNC symbol
- CERS1
- Aliases
- EPM8; LAG1; UOG1; LASS1
- Common name
- ceramide synthase 1
- Description
- This gene encodes a ceramide synthase enzyme, which catalyzes the synthesis of ceramide, the hydrophobic moiety of sphingolipids. The encoded enzyme synthesizes 18-carbon (C18) ceramide in brain neurons. Elevated expression of this gene may be associated with increased longevity, while decreased expression of this gene may be associated with myoclonus epilepsy with dementia in human patients. This protein is transcribed from a monocistronic mRNA as well as a bicistronic mRNA, which also encodes growth differentiation factor 1. [provided by RefSeq, Jul 2016]
- Other longevity studies of this gene
- 1
- OMIM
- 606919
- Ensembl
- ENSG00000223802
- UniProt/Swiss-Prot
- B4DE47_HUMAN
- Entrez Gene
- 10715
- UniGene
- 412355
- HapMap
- View on HapMap