LongevityMap Gene
Gene details
- HGNC symbol
- CERS1
- Aliases
- EPM8; LAG1; UOG1; LASS1
- Common name
- ceramide synthase 1
- Description
- This gene encodes a ceramide synthase enzyme, which catalyzes the synthesis of ceramide, the hydrophobic moiety of sphingolipids. The encoded enzyme synthesizes 18-carbon (C18) ceramide in brain neurons. Elevated expression of this gene may be associated with increased longevity, while decreased expression of this gene may be associated with myoclonus epilepsy with dementia in human patients. This protein is transcribed from a monocistronic mRNA as well as a bicistronic mRNA, which also encodes growth differentiation factor 1. [provided by RefSeq, Jul 2016]
- Cytogenetic Location
- 19p13.11
- UCSC Genome Browser
- View 19p13.11 on the UCSC genome browser
- OMIM
- 606919
- Ensembl
- ENSG00000223802
- UniProt/Swiss-Prot
- B4DE47_HUMAN
- Entrez Gene
- 10715
- UniGene
- 412355
- 1000 Genomes
- 1000 Genomes
Homologs in model organisms
- Caenorhabditis elegans
- tig-2
- Danio rerio
- gdf3
- Drosophila melanogaster
- scw
- Mus musculus
- Gdf1
- Mus musculus
- Cers1
- Rattus norvegicus
- Gdf1
Studies (2)
Significant/Non-significant: 1/1
Study 1
- Longevity Association
- Significant
- Population
- American (Georgia and Louisiana populations from African and European origin)
- Study Design
- Haplotype analysis was performed in three candidate genes, and the haplotype combinations were tested for association with exceptional longevity in the Georgia Centenarian Study (n=650) and Louisiana Healthy Aging Study (n=869)
- Conclusions
- An HRAS1 haplotype enhanced the effect of an APOE haplotype on exceptional survival, and a LASS1 haplotype further augmented its magnitude. These results were replicated in a second population.
- Indentifier
- CERS1
- Reference
Study 2
- Longevity Association
- Non-significant
- Population
- American (Georgia and Louisiana populations from African and European origin)
- Study Design
- Subjects were recruited and stratified according to their genetically inferred ethnic affiliation to account for population structure. Haplotype analysis was performed in three candidate genes, and the haplotype combinations were tested for association with exceptional longevity.
- Conclusions
- LASS1 and HRAS1 were not individually associated with longevity
- Indentifier
- CERS1
- Reference