LongevityMap variant
Entry Details
- Longevity Association
- Significant
- Population
- Chinese (Uighur in Xinjiang)
- Study Design
- Case-control study in 191 healthy individuals greater than 90 years of age, and 53 naturally died persons 65-70 years of age on A1267G in HSPA1B, G190C in HSPA1A, and T2437C in HSPA1L
- Conclusions
- In single-locus analysis, no significant differences were found between long-lived people and short-lived people in the genotype/allele distributions of all variants. In contrast, haplotype analysis indicated that haplotypes A-G-C and A-C-T were more prevalent in long-lived people than short-lived people (P=0.026 and 0.017), and the analysis conferred a 3.46- and 4.51-fold increased tendency for longevity, respectively (P=0.025 and 0.016).
- Identifier
- T2437C
- In Other Studies (IDs)
- 106 378
- Cytogenetic Location
- 6p21.33
- UCSC Genome Browser
- View 6p21.33 on the UCSC genome browser
Gene details
- HGNC symbol
- HSPA1L
- Aliases
- HSP70T; hum70t; HSP70-1L; HSP70-HOM
- Common name
- heat shock protein family A (Hsp70) member 1 like
- Description
- This gene encodes a 70kDa heat shock protein. In conjunction with other heat shock proteins, this protein stabilizes existing proteins against aggregation and mediates the folding of newly translated proteins in the cytosol and in organelles. The gene is located in the major histocompatibility complex class III region, in a cluster with two closely related genes which also encode isoforms of the 70kDa heat shock protein. [provided by RefSeq, Jul 2008]
- Other longevity studies of this gene
- 8
- OMIM
- 140559
- Ensembl
- ENSG00000204390
- UniProt/Swiss-Prot
- HS71L_HUMAN
- Entrez Gene
- 3305
- UniGene
- 690634
- HapMap
- View on HapMap