LongevityMap variant
Entry Details
- Longevity Association
- Significant
- Population
- Irish
- Study Design
- The frequency of the T2437C transversion (Met to Thr) polymorphism was investigated in a healthy aged population of 100 control samples (59% female, 41% male with an age-range of 19-45 years) and 129 aged consecutive samples (70% female, 30% male with an age range of 80-97 years)
- Conclusions
- The 2437T polymorphic nucleotide was observed to increase in the elderly, although not attaining statistical significance. The TT genotype was observed to be significantly increased within the aged population, while conversely the TC genotype was significantly decreased in the aged subjects.
- Identifier
- T2437C
- In Other Studies (IDs)
- 378 492
- Cytogenetic Location
- 6p21.33
- UCSC Genome Browser
- View 6p21.33 on the UCSC genome browser
Gene details
- HGNC symbol
- HSPA1L
- Aliases
- HSP70T; hum70t; HSP70-1L; HSP70-HOM
- Common name
- heat shock protein family A (Hsp70) member 1 like
- Description
- This gene encodes a 70kDa heat shock protein. In conjunction with other heat shock proteins, this protein stabilizes existing proteins against aggregation and mediates the folding of newly translated proteins in the cytosol and in organelles. The gene is located in the major histocompatibility complex class III region, in a cluster with two closely related genes which also encode isoforms of the 70kDa heat shock protein. [provided by RefSeq, Jul 2008]
- Other longevity studies of this gene
- 8
- OMIM
- 140559
- Ensembl
- ENSG00000204390
- UniProt/Swiss-Prot
- HS71L_HUMAN
- Entrez Gene
- 3305
- UniGene
- 690634
- HapMap
- View on HapMap