LongevityMap variant
Entry Details
- Longevity Association
- Significant
- Population
- Danish
- Study Design
- Alleles in candidate pathways (GH/IGF1 signaling, DNA damage signaling and repair and pro/antioxidants) were investigated for association with longevity in 1089 oldest-old (age 92-93) and 736 middle-aged Danes
- Conclusions
- Eleven SNPs (in GSR, KL, GHRHR, INS, GHSR, IGF2R, RAD52, WRN, RAD23B, POLB and NTLH1) were associated with longevity after correction for multiple hypothesis testing. No replications were observed in German and Dutch populations.
- Identifier
- rs3842755
- Cytogenetic Location
- 11p15.5
- UCSC Genome Browser
- View 11p15.5 on the UCSC genome browser
Gene details
- HGNC symbol
- INS
- Aliases
- IDDM; ILPR; IRDN; IDDM1; IDDM2; MODY10
- Common name
- insulin
- Description
- After removal of the precursor signal peptide, proinsulin is post-translationally cleaved into three peptides: the B chain and A chain peptides, which are covalently linked via two disulfide bonds to form insulin, and C-peptide. Binding of insulin to the insulin receptor (INSR) stimulates glucose uptake. A multitude of mutant alleles with phenotypic effects have been identified. There is a read-through gene, INS-IGF2, which overlaps with this gene at the 5' region and with the IGF2 gene at the 3' region. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2010]
- Other longevity studies of this gene
- 5
- OMIM
- 176730
- Ensembl
- ENSG00000254647
- UniProt/Swiss-Prot
- I3WAC9_HUMAN
- Entrez Gene
- 3630
- UniGene
- 272259
- HapMap
- View on HapMap
Homologs in model organisms
- Danio rerio
- ins
- Danio rerio
- insb
- Mus musculus
- Ins2
- Mus musculus
- Ins1
- Rattus norvegicus
- Ins1
- Rattus norvegicus
- Ins2
In other databases
- GenAge human genes
- This gene is present as INS