LongevityMap Gene

Gene details

HGNC symbol: INS
Aliases: IDDM; ILPR; IRDN; IDDM1; IDDM2; MODY10
Common name: insulin
Description: After removal of the precursor signal peptide, proinsulin is post-translationally cleaved into three peptides: the B chain and A chain peptides, which are covalently linked via two disulfide bonds to form insulin, and C-peptide. Binding of insulin to the insulin receptor (INSR) stimulates glucose uptake. A multitude of mutant alleles with phenotypic effects have been identified. There is a read-through gene, INS-IGF2, which overlaps with this gene at the 5' region and with the IGF2 gene at the 3' region. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2010]
Cytogenetic Location: 11p15.5
UCSC Genome Browser: View 11p15.5 on the UCSC genome browser
OMIM: 176730
Ensembl: ENSG00000254647
UniProt/Swiss-Prot: I3WAC9_HUMAN
Entrez Gene: 3630
UniGene: 272259
1000 Genomes: 1000 Genomes

Homologs in model organisms

Danio rerio: ins
Danio rerio: insb
Mus musculus: Ins2
Mus musculus: Ins1
Rattus norvegicus: Ins1
Rattus norvegicus: Ins2

In other databases

GenAge human genes

This gene is present as INS

Studies (6)

Significant/Non-significant: 2/4

Study 1

Longevity Association

Non-significant

Population

Study Design

FokI RFLP polymorphism was examined in 219 centenarians (72 males and 147 females) and 256 (controls 20-70 years, 119 males and 137 females)

Conclusions

No significant difference between centenarians and controls was observed

Indentifier

Reference

Study 2

Longevity Association

Non-significant

Population

Study Design

VNTR repeat (promoter) was examined in 1576 individuals aged >85

Conclusions

No significant association with longevity was found

Indentifier

Reference

Study 3

Longevity Association: Significant
Population: Danish
Study Design: Alleles in candidate pathways (GH/IGF1 signaling, DNA damage signaling and repair and pro/antioxidants) were investigated for association with longevity in 1089 oldest-old (age 92-93) and 736 middle-aged Danes
Conclusions: Eleven SNPs (in GSR, KL, GHRHR, INS, GHSR, IGF2R, RAD52, WRN, RAD23B, POLB and NTLH1) were associated with longevity after correction for multiple hypothesis testing. No replications were observed in German and Dutch populations.
Indentifier

Study 4

Longevity Association

Population

Study Design

Studied genetic variation in the insulin/insulin-like growth factor signaling (IIS) pathway and in the telomere maintenance pathway for associations with longevity in 403 unrelated nonagenarians and 1,670 younger controls

Conclusions

SNP sets in both pathways were associated with longevity with the association of the IIS pathway defined by several genes (AKT1, AKT3, FOXO4, IGF2, INS, PIK3CA, SGK, SGK2, and YWHAG), while the telomere maintenance pathway seemed to be mainly determined by POT1 since only these genes showed an association with longevity

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Reference

Study 5

Longevity Association

Non-significant

Population

Study Design

The chromosomal region 11p.15.5 was investigated in 1321 centenarians and 1140 younger subjects from European samples

Conclusions

No significant results were observed for genes previously associated with longevity: TH, IGF2, INS and HRAS1

Indentifier

Reference

Study 6

Longevity Association: Non-significant
Population: Italian (Southern)
Study Design: A two-stage case-control study was performed to identify the association between longevity and variation of in homeostasis regulation pathway genes. 317 SNPs in 104 genes were analyzed in 78 cases (≥90 years, median age 98 years, 42 females) and 71 controls (<90 years, median age 67 years, 32 females) in stage 1. Then, 31 candidate SNPs identified in stage 1 (π markers = 0.1) were analyzed in an independent sample composed by 288 cases (≥90 years, median age 92 years, 163 females) and 554 controls (<90 years, median age 67 years, 277 females).
Conclusions: After adjustment for multiple testing, no significant association was identified between various SNPs and longevity.
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