LongevityMap variant
- Longevity Association
- Significant
- Population
- Danish
- Study Design
- IL6 (−597G/A, −572G/C and −174G/C) and the AT-stretch polymorphism (−373(A)n(T)m) were examined in 1710 Danish subjecta (47- 100y) to detect if a specific genotype or haplotype was associated with either longevity or increased mortality.
- Conclusions
- There was an almost complete allelic association between the −597G allele and the −174G allele. A modest, but significant, increase in the frequency of interleukin-6 −174GG homozygotes with age was observed. This genotype is advantageous for longevity.
- HGNC symbol
- IL6
- Aliases
- CDF; HGF; HSF; BSF2; IL-6; BSF-2; IFNB2; IFN-beta-2
- Common name
- interleukin 6
- Description
- This gene encodes a cytokine that functions in inflammation and the maturation of B cells. In addition, the encoded protein has been shown to be an endogenous pyrogen capable of inducing fever in people with autoimmune diseases or infections. The protein is primarily produced at sites of acute and chronic inflammation, where it is secreted into the serum and induces a transcriptional inflammatory response through interleukin 6 receptor, alpha. The functioning of this gene is implicated in a wide variety of inflammation-associated disease states, including suspectibility to diabetes mellitus and systemic juvenile rheumatoid arthritis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]
- Other longevity studies of this gene
- 19
- OMIM
- 147620
- Ensembl
- ENSG00000136244
- UniProt/Swiss-Prot
- B4DNQ5_HUMAN
- Entrez Gene
- 3569
- UniGene
- 654458
- HapMap
- View on HapMap
Homologs in model organisms
- Mus musculus
- Il6
- Rattus norvegicus
- Il6
- GenAge human genes
- This gene is present as IL6
- CellAge
- This gene is present as IL6
Christiansen et al. (2004)
Other variants which are also part of this study
